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Details on Person TRADD:TRAF2:RIP1:FADD binds pro-caspase 8

Class:IdReaction:75240
_displayNameTRADD:TRAF2:RIP1:FADD binds pro-caspase 8
_doReleaseTRUE
_timestamp2024-09-04 19:09:48
compartment[Compartment:70101] cytosol
created[InstanceEdit:110071] Tschopp, Jürg, 2004-01-28
edited[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
input[EntityWithAccessionedSequence:57031] CASP8(1-479) [cytosol] [Homo sapiens]
[Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
modified[InstanceEdit:83535] Matthews, L, 2003-11-18 00:00:00
[InstanceEdit:83604] Matthews, L, 2003-11-23 12:20:00
[InstanceEdit:83683] Matthews, L, 2003-11-27 03:00:00
[InstanceEdit:83892] Matthews, L, 2003-12-10 03:30:00
[InstanceEdit:109917] Joshi-Tope, G, 2004-01-22 15:11:19
[InstanceEdit:110070] Joshi-Tope, G, 2004-01-28 14:40:07
[InstanceEdit:140987] Gillespie, ME, 2004-08-25 17:33:55
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:451053] Matthews, L, 2009-12-28
[InstanceEdit:2648974] D'Eustachio, P, 2012-11-21
[InstanceEdit:3597633] Shamovsky, V, 2013-05-22
[InstanceEdit:5433129] Shamovsky, V, 2014-05-12
[InstanceEdit:5545561] Shamovsky, Veronica, 2014-05-22
[InstanceEdit:5693173] Shamovsky, Veronica, 2015-05-14
[InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9828540] Shamovsky, Veronica, 2023-02-15
[InstanceEdit:9829017] Shamovsky, Veronica, 2023-02-21
[InstanceEdit:9830261] Shamovsky, Veronica, 2023-03-01
[InstanceEdit:9920910] Shamovsky, Veronica, 2024-09-04
nameTRADD:TRAF2:RIP1:FADD binds pro-caspase 8
output[Complex:140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:5692563] Negative regulation by 'CASP8(1-479):UL36 [cytosol]'
[NegativeRegulation:9828541] Negative regulation by 'OPTN:CASP8 [cytosol]'
regulationReference[RegulationReference:9641752] Negative regulation by 'CASP8(1-479):UL36 [cytosol]' A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation
[RegulationReference:9828539] Negative regulation by 'OPTN:CASP8 [cytosol]' Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
relatedSpecies[Species:2671791] Human cytomegalovirus
releaseDate2004-10-27
reviewed[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
[InstanceEdit:9828415] Munitić, Ivana, 2023-02-14
[InstanceEdit:9830259] Franjkić, Toni, 2023-03-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360371] R-HSA-75240.7
structureModified[InstanceEdit:9828540] Shamovsky, Veronica, 2023-02-15
summation[Summation:179240] Tumor necrosis factor α (TNF-α)-induced apoptosis is regulat...
(hasEvent)[Pathway:5357786] TNFR1-induced proapoptotic signaling [Homo sapiens]
(precedingEvent)[Reaction:141159] TNF-mediated dimerization of procaspase-8 [Homo sapiens]
[Reaction:3465429] FLIP(S) and procaspase-8 form heterodimer [Homo sapiens]
[Reaction:5675456] FLIP(L) and procaspase-8 form heterodimer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784359] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v54:[addRegulator]
[_UpdateTracker:9788121] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v43:[modifyText]
[_UpdateTracker:9846759] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v84:[addRegulator, modifyText]
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