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Details on Person TRAIL:TRAIL receptor trimers bind FADD

Class:IdReaction:75187
_displayNameTRAIL:TRAIL receptor trimers bind FADD
_doReleaseTRUE
_timestamp2016-11-10 00:56:53
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:110071] Tschopp, Jürg, 2004-01-28
edited[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input[EntityWithAccessionedSequence:54639] FADD [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:54639] FADD [cytosol] [Homo sapiens]
[Complex:5637469] TNFSF10:TNFRSF10A,B Trimer [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:141128] FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
[LiteratureReference:3371373] Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
modified[InstanceEdit:83535] Matthews, L, 2003-11-18 00:00:00
[InstanceEdit:109917] Joshi-Tope, G, 2004-01-22 15:11:19
[InstanceEdit:110070] Joshi-Tope, G, 2004-01-28 14:40:07
[InstanceEdit:141144] Gillespie, ME, 2004-09-02 19:10:08
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:2648974] D'Eustachio, P, 2012-11-21
[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
[InstanceEdit:3465520] Shamovsky, V, 2013-05-17
[InstanceEdit:3597633] Shamovsky, V, 2013-05-22
[InstanceEdit:3632866] Shamovsky, V, 2013-05-28
[InstanceEdit:5634844] Orlic-Milacic, Marija, 2014-11-06
[InstanceEdit:5635726] Orlic-Milacic, Marija, 2014-11-07
[InstanceEdit:5637454] Orlic-Milacic, Marija, 2014-11-10
[InstanceEdit:5637470] Orlic-Milacic, Marija, 2014-11-10
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTRAIL:TRAIL receptor trimers bind FADD
output[Complex:5637464] TNFSF10:TNFRSF10A,B:FADD [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:141117] Negative regulation by 'CFLAR(1-376) [cytosol]'
releaseDate2004-10-27
reviewed[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
[InstanceEdit:5634834] Orlic-Milacic, Marija, 2014-11-06
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:362019] R-HSA-75187.4
summation[Summation:179245] The trimeric complex of TRAIL and TRAIL receptor-1 (TNFSF10:...
(hasEvent)[Pathway:75158] TRAIL signaling [Homo sapiens]
(precedingEvent)[Reaction:75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 [Homo sapiens]
[Reaction:141316] TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 [Homo sapiens]
[Reaction:5334738] HPV Suppressed TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785587] Update Tracker - [Reaction:75187] TRAIL:TRAIL receptor trimers bind FADD - v51:[add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9787337] Update Tracker - [Reaction:75187] TRAIL:TRAIL receptor trimers bind FADD - v45:[addLiteratureReference]
[_UpdateTracker:9788286] Update Tracker - [Reaction:75187] TRAIL:TRAIL receptor trimers bind FADD - v43:[modifyText]
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No pathways have been reviewed or authored by TRAIL:TRAIL receptor trimers bind FADD (75187)
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