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Details on Person PKC phosphorylates G alpha (z)

Class:Id	Reaction:751040
_displayName	PKC phosphorylates G alpha (z)
_doRelease	TRUE
_timestamp	2017-07-11 09:40:30
authored	[InstanceEdit:749459] Jupe, S, 2010-05-18
catalystActivity	[CatalystActivity:804937] diacylglycerol-dependent serine/threonine kinase activity of G-alpha(z):GTP:PKC [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:751025] Jupe, S, 2010-05-19
edited	[InstanceEdit:791501] Jupe, S, 2010-05-24
inferredFrom	[Reaction:804924] PKC (cow) phosphorylates G alpha z (rat) [Bos taurus]
input	[Complex:8982710] G-alpha(z):GTP:PKC [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:751038] Phosphorylation of Gz in human platelets. Selectivity and site of modification [LiteratureReference:8982701] Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex
modified	[InstanceEdit:804938] Jupe, S, 2010-05-26 [InstanceEdit:827352] Jupe, S, 2010-05-27 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PKC phosphorylates G alpha (z)
output	[Complex:8982705] p(S27)-G-alpha(z):GTP:PKC [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:8982703] PKC binds active G alpha (z) [Homo sapiens] [Reaction:751024] The Ligand:GPCR:Gz complex dissociates [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105573] R-HSA-751040.3
summation	[Summation:750990] G alpha z (Lounsbury et al. 1991) and G alpha 12 (Kozasa & G...
(hasEvent)	[Pathway:418597] G alpha (z) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:8982709] G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781459] Update Tracker - [Reaction:751040] PKC phosphorylates G alpha (z) - v61:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by PKC phosphorylates G alpha (z) (751040)