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Details on Person Liganded G12/13-activating GPCR acts as a GEF for G12/13

Class:Id	Reaction:751029
_displayName	Liganded G12/13-activating GPCR acts as a GEF for G12/13
_doRelease	TRUE
_timestamp	2010-12-02 14:34:52
authored	[InstanceEdit:392024] Jupe, S, 2009-02-26 15:51:29
catalystActivity	[CatalystActivity:763959] guanyl-nucleotide exchange factor activity of Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:751025] Jupe, S, 2010-05-19
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[Complex:750994] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:751004] Regulation and physiological functions of G12/13-mediated signaling pathways
modified	[InstanceEdit:763958] Jupe, S, 2010-05-20 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded G12/13-activating GPCR acts as a GEF for G12/13
output	[Complex:751015] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 [Homo sapiens] [Reaction:391939] TP receptor can bind thromboxane [Homo sapiens] [Reaction:390641] ADRA1A,B,D bind ADR,NAd [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104600] R-HSA-751029.2
summation	[Summation:751022] The liganded receptor undergoes a conformational change, gen...
(hasEvent)	[Pathway:416482] G alpha (12/13) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:751019] The Ligand:GPCR:G12/13 complex dissociates [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781637] Update Tracker - [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - v60:[modifyText] [_UpdateTracker:9939757] Update Tracker - [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - v92:[modifyText]
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