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Details on Person Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Class:Id	Reaction:751027
_displayName	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
_doRelease	TRUE
_timestamp	2010-12-02 14:37:58
authored	[InstanceEdit:745612] Jupe, S, 2010-05-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:751025] Jupe, S, 2010-05-19
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[DefinedSet:751003] Ligand:GPCR complexes that activate G12/13 [plasma membrane] [Homo sapiens] [DefinedSet:398082] G-protein G12/G13 (inactive) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:750992] Receptors coupled to heterotrimeric G proteins of the G12 family [LiteratureReference:448849] Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology [LiteratureReference:751000] Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy
modified	[InstanceEdit:804958] Jupe, S, 2010-05-26 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
output	[Complex:750994] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:391939] TP receptor can bind thromboxane [Homo sapiens] [Reaction:390641] ADRA1A,B,D bind ADR,NAd [Homo sapiens] [Reaction:9623384] α1-agonists bind ADRA1A,B,D [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105151] R-HSA-751027.2
summation	[Summation:804956] About 25 receptors are reported to couple to the G12/13 G pr...
(hasEvent)	[Pathway:416482] G alpha (12/13) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 [Homo sapiens]
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No pathways have been reviewed or authored by Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (751027)