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Details on Person The Ligand:GPCR:Gz complex dissociates
Class:Id Reaction:751024 _displayName The Ligand:GPCR:Gz complex dissociates _doRelease TRUE _timestamp 2017-07-11 09:41:08 authored [InstanceEdit:744889] Jupe, S, 2010-05-18 compartment [Compartment:984] extracellular region [Compartment:876] plasma membrane created [InstanceEdit:751025] Jupe, S, 2010-05-19 edited [InstanceEdit:813668] Jupe, S, 2010-05-26 input [Complex:751030] ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells modified [InstanceEdit:791496] Jupe, S, 2010-05-24 [InstanceEdit:804958] Jupe, S, 2010-05-26 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8944096] Jupe, Steve, 2016-11-02 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name The Ligand:GPCR:Gz complex dissociates output [Complex:392003] G-protein alpha (z):GTP [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [DefinedSet:390664] ADRA2A,B,C [plasma membrane] [Homo sapiens] [DefinedSet:390627] ADR, NAd [extracellular region] precedingEvent
releaseDate 2010-06-15 reviewed [InstanceEdit:782850] D'Eustachio, P, 2010-05-21 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1105345] R-HSA-751024.4 summation [Summation:804948] The classical view of G-protein signalling is that the G-pro... (hasEvent) [Pathway:418597] G alpha (z) signalling events [Homo sapiens] (precedingEvent) [Reaction:392064] G alpha (z) inhibits adenylate cyclase [Homo sapiens] [Reaction:392133] G alpha (z) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] [Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens] [Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens] [Reaction:8978882] G-protein beta-gamma complex binds to voltage-gated calcium channel [Homo sapiens] [Reaction:8981892] Active G alpha (z) binds RGS proteins [Homo sapiens] (updatedInstance) [_UpdateTracker:9782270] Update Tracker - [Reaction:751024] The Ligand:GPCR:Gz complex dissociates - v59:[add_removeOutput]
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