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Details on Person The Ligand:GPCR:G12/13 complex dissociates

Class:Id	Reaction:751019
_displayName	The Ligand:GPCR:G12/13 complex dissociates
_doRelease	TRUE
_timestamp	2010-12-02 14:33:18
authored	[InstanceEdit:744889] Jupe, S, 2010-05-18
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:751025] Jupe, S, 2010-05-19
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[Complex:751015] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified	[InstanceEdit:791499] Jupe, S, 2010-05-24 [InstanceEdit:804958] Jupe, S, 2010-05-26 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:939142] Jupe, S, 2010-08-31 [InstanceEdit:939143] Jupe, S, 2010-08-31 [InstanceEdit:939144] Jupe, S, 2010-08-31 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The Ligand:GPCR:G12/13 complex dissociates
output	[DefinedSet:791500] GPCRs that activate G12/13 [plasma membrane] [Homo sapiens] [DefinedSet:791498] Ligands of GPCRs that activate G12/13 [extracellular region] [DefinedSet:418572] G-protein alpha (12/13):GTP [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 [Homo sapiens] [Reaction:751027] Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104305] R-HSA-751019.2
summation	[Summation:804947] The classical view of G-protein signalling is that the G-pro...
(hasEvent)	[Pathway:416482] G alpha (12/13) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) [Homo sapiens] [Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:398184] LARG activation by G alpha 12/13 [Homo sapiens] [Reaction:418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] [Reaction:8964274] G alpha (12) binds BTK [Homo sapiens] [Reaction:8964301] G alpha (12) binds to RASA2 [Homo sapiens] [Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens] List all 12 refering instances
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No pathways have been reviewed or authored by The Ligand:GPCR:G12/13 complex dissociates (751019)