Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person G alpha z (Lounsbury et al. 1991) and G alpha 12 (Kozasa & G...
| Class:Id | Summation:750990 |
|---|---|
| _displayName | G alpha z (Lounsbury et al. 1991) and G alpha 12 (Kozasa & G... |
| _timestamp | 2017-03-22 10:38:07 |
| created | [InstanceEdit:751025] Jupe, S, 2010-05-19 |
| literatureReference | [LiteratureReference:751014] Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma [LiteratureReference:751037] Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than Gi in human platelets [LiteratureReference:751016] Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation |
| modified | [InstanceEdit:804917] Jupe, S, 2010-05-26 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 |
| text | G alpha z (Lounsbury et al. 1991) and G alpha 12 (Kozasa & Gilman, 1996) are excellent in vitro substrates for all three subtypes of protein kinase C (PKC). Activation of PKC in intact platelets by agents such as thrombin, thromboxane A2 (TXA2) analogues and phorbol esters leads to rapid and near-stoichiometric phosphorylation of G alpha z (Carlson et al. 1989). The primary phosphorylation site is Ser-27 (Lounsbury et al. 1993). This phosphorylation blocks the interaction of G alpha z with Gbeta:gamma suggesting that it is a regulatory mechanism for attenuating signalling by preventing subunit reassociation. |
| (summation) | [Reaction:751040] PKC phosphorylates G alpha (z) [Homo sapiens] [Reaction:804924] PKC (cow) phosphorylates G alpha z (rat) [Bos taurus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by G alpha z (Lounsbury et al. 1991) and G alpha 12 (Kozasa & G... (750990)
