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Details on Person Transport of the export-competent mRNP complex through the NPC
Class:Id BlackBoxEvent:75097 _displayName Transport of the export-competent mRNP complex through the NPC _doRelease TRUE _timestamp 2020-09-28 15:14:30 compartment [Compartment:13231] nuclear envelope [Compartment:70101] cytosol [Compartment:7660] nucleoplasm created [InstanceEdit:75101] Hammarskjold, ML, 2003-08-22 13:02:53 goBiologicalProcess [GO_BiologicalProcess:4519] mRNA export from nucleus input [Complex:113815] NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] [Homo sapiens] literatureReference [LiteratureReference:8850715] TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus [LiteratureReference:8850681] The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences [LiteratureReference:8850709] The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human [LiteratureReference:8850685] NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells [LiteratureReference:8850696] Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export [LiteratureReference:8850694] Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes [LiteratureReference:8850714] Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex [LiteratureReference:8850731] RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex [LiteratureReference:8932903] The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export modified [InstanceEdit:75100] Joshi-Tope, G, 2003-08-22 12:57:00 [InstanceEdit:113813] Joshi-Tope, G, 2004-06-23 01:24:22 [InstanceEdit:159238] Gillespie, ME, 2005-02-27 15:27:47 [InstanceEdit:159260] Gillespie, ME, 2005-02-28 22:35:45 [InstanceEdit:159335] Gillespie, ME, 2005-03-03 03:44:22 [InstanceEdit:162431] Gillespie, ME, 2005-03-28 12:41:43 [InstanceEdit:162441] Joshi-Tope, G, 2005-03-28 16:33:16 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8849163] May, Bruce, 2015-12-14 [InstanceEdit:8850739] May, Bruce, 2015-12-27 [InstanceEdit:8850873] May, Bruce, 2016-01-01 [InstanceEdit:8858392] May, Bruce, 2016-02-19 [InstanceEdit:8932907] May, Bruce, 2016-07-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8961727] May, Bruce, 2017-02-04 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9701952] D'Eustachio, Peter, 2020-09-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Transport of the export-competent mRNP complex through the NPC output [Complex:159259] NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] [Homo sapiens] precedingEvent
regulatedBy [Requirement:159295] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:8961718] Requirement by 'GLE1 [nucleoplasm]' regulationReference [RegulationReference:9642012] Requirement by 'GLE1 [nucleoplasm]' Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease [RegulationReference:9701951] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human releaseDate 2004-07-06 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:359890] R-HSA-75097.9 summation [Summation:179269] In this reaction, 1 molecule of 'Export... (hasEvent) [Pathway:159236] Transport of Mature mRNA derived from an Intron-Containing Transcript [Homo sapiens] (precedingEvent) [Reaction:75098] mRNP complex dissociates from cytosolic face of NPC [Homo sapiens] (updatedInstance) [_UpdateTracker:9776587] Update Tracker - [BlackBoxEvent:75097] Transport of the export-competent mRNP complex through the NPC - v75:[removeCatalystActivity] [_UpdateTracker:9781957] Update Tracker - [BlackBoxEvent:75097] Transport of the export-competent mRNP complex through the NPC - v60:[addRegulator] [_UpdateTracker:9782763] Update Tracker - [BlackBoxEvent:75097] Transport of the export-competent mRNP complex through the NPC - v58:[addLiteratureReference] [_UpdateTracker:9783516] Update Tracker - [BlackBoxEvent:75097] Transport of the export-competent mRNP complex through the NPC - v56:[addCatalystActivity, addLiteratureReference]
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