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Details on Person Docking of the TAP:EJC Complex with the NPC

Class:IdReaction:75096
_displayNameDocking of the TAP:EJC Complex with the NPC
_doReleaseTRUE
_timestamp2016-11-10 00:56:27
compartment[Compartment:7660] nucleoplasm
[Compartment:13231] nuclear envelope
created[InstanceEdit:75101] Hammarskjold, ML, 2003-08-22 13:02:53
goBiologicalProcess[GO_BiologicalProcess:4519] mRNA export from nucleus
input[Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Homo sapiens]
[Complex:159100] NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:8850715] TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
[LiteratureReference:8850681] The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
[LiteratureReference:8850709] The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
[LiteratureReference:8850720] The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
[LiteratureReference:8850684] Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins
[LiteratureReference:8850694] Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes
[LiteratureReference:8850702] Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling
[LiteratureReference:8850731] RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex
modified[InstanceEdit:75100] Joshi-Tope, G, 2003-08-22 12:57:00
[InstanceEdit:113813] Joshi-Tope, G, 2004-06-23 01:24:22
[InstanceEdit:159266] Gillespie, ME, 2005-02-28 22:36:22
[InstanceEdit:159338] Gillespie, ME, 2005-03-03 03:44:38
[InstanceEdit:159643] Joshi-Tope, G, 2005-03-12 01:00:55
[InstanceEdit:162449] Joshi-Tope, G, 2005-03-28 18:56:30
[InstanceEdit:162453] Joshi-Tope, G, 2005-03-28 19:19:09
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5688094] Jupe, Steve, 2015-04-14
[InstanceEdit:5688095] Jupe, Steve, 2015-04-14
[InstanceEdit:5693413] Jupe, Steve, 2015-05-15
[InstanceEdit:5693659] Jupe, Steve, 2015-05-18
[InstanceEdit:5693938] Jupe, Steve, 2015-05-19
[InstanceEdit:5694013] Jupe, Steve, 2015-05-20
[InstanceEdit:8849163] May, Bruce, 2015-12-14
[InstanceEdit:8850669] May, Bruce, 2015-12-24
[InstanceEdit:8850672] May, Bruce, 2015-12-24
[InstanceEdit:8850739] May, Bruce, 2015-12-27
[InstanceEdit:8852187] May, Bruce, 2016-01-13
[InstanceEdit:8866659] May, Bruce, 2016-04-03
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDocking of the TAP:EJC Complex with the NPC
output[Complex:113815] NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72031] SRSF1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72033] SRSF2 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72024] SRSF4 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72058] SRSF11 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72029] SRSF7 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72037] SRSF9 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72035] SRSF3 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72028] SRSF5 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72026] SRSF6 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72073] hSLU7 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72060] DHX38 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72062] CDC40 [nucleoplasm] [Homo sapiens]
[DefinedSet:8865886] U2AF1,U2AF1L4 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:71987] U2AF2 [nucleoplasm] [Homo sapiens]
[Complex:8849128] THO complex [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8849147] CHTOP [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8849146] SARNP [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8850659] ZC3H11A [nucleoplasm] [Homo sapiens]
[CandidateSet:8852182] ALYREF, FYTTD1, LUZP4 [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[Requirement:159293] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358889] R-HSA-75096.6
summation[Summation:178695] At the beginning of this reaction, 1 molecule of 'TAP:3'-pol...
(hasEvent)[Pathway:159236] Transport of Mature mRNA derived from an Intron-Containing Transcript [Homo sapiens]
(precedingEvent)[BlackBoxEvent:75097] Transport of the export-competent mRNP complex through the NPC [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783012] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v57:[add_removeOutput]
[_UpdateTracker:9783610] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v56:[addInput, addLiteratureReference, add_removeOutput]
[_UpdateTracker:9784617] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v53:[removeOutput]
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