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Details on Person UniProt:P07527 wee1

Class:Id	ReferenceGeneProduct:75025
_chainChangeLog	chain:1-877 added on Fri February 6 2015
_displayName	UniProt:P07527 wee1
_timestamp	2025-02-21 19:03:18
chain	chain:1-877
checksum	C8B5113D66C39D10
comment	FUNCTION Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Binds 2 magnesium ions per subunit.ACTIVITY REGULATION Negatively regulated by phosphorylation in the M-phase.SUBCELLULAR LOCATION Phosphorylated in the C-terminal by NIM1/CDR1.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
description	recommendedName: Mitosis inhibitor protein kinase wee1 ecNumber: 2.7.10.2 alternativeName: P107 protein kinase homolog
geneName	wee1 SPCC18B5.03
identifier	P07527
isSequenceChanged	FALSE
keyword	ATP-binding Cell cycle Cell division Kinase Magnesium Metal-binding Mitosis Nucleotide-binding Nucleus Phosphoprotein Reference proteome Transferase Tyrosine-protein kinase
modified	[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	wee1
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	WEE1_SCHPO Q9UU00
sequenceLength	877
species	[Species:68324] Schizosaccharomyces pombe
(referenceEntity)	[EntityWithAccessionedSequence:156490] phospho-Wee1 Pombe [nucleoplasm] [Schizosaccharomyces pombe] [EntityWithAccessionedSequence:156495] Wee1 POMBE [nucleoplasm] [Schizosaccharomyces pombe]
(referenceSequence)	[ModifiedResidue:109455] O-phospho-L-serine at unknown position
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No pathways have been reviewed or authored by UniProt:P07527 wee1 (75025)