Query author contributions in Reactome
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Details on Person Cdc25C is phosphorylated by Chk1 at ser-216 (Blasina et al.,...
| Class:Id | Summation:75023 |
|---|---|
| _displayName | Cdc25C is phosphorylated by Chk1 at ser-216 (Blasina et al.,... |
| _timestamp | 2003-08-08 07:39:40 |
| created | [InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00 |
| literatureReference | [LiteratureReference:75008] A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase [LiteratureReference:75011] Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. |
| text | Cdc25C is phosphorylated by Chk1 at ser-216 (Blasina et al.,1999 ) resulting in both inhibition of the Cdc25 phosphatase activity and creation of a 14-3-3 docking site (Peng et al., 1997). Association of 14-3-3 protein is believed to exclude Cdc25C from the nucleus via cytoplasmic retention of the Cdc25C:14-3-3 complex. |
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No pathways have been reviewed or authored by Cdc25C is phosphorylated by Chk1 at ser-216 (Blasina et al.,... (75023)
