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Details on Person Association of p-S216-CDC25C with 14-3-3 proteins

Class:Id	Reaction:75016
_displayName	Association of p-S216-CDC25C with 14-3-3 proteins
_doRelease	TRUE
_timestamp	2018-12-13 17:30:40
authored	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
input	[EntityWithAccessionedSequence:75003] p-S216-CDC25C [cytosol] [Homo sapiens] [DefinedSet:1445138] 14-3-3 dimer [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:75008] A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase [LiteratureReference:75011] Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. [LiteratureReference:75019] Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. [LiteratureReference:75017] Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.
modified	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00 [InstanceEdit:75046] Matthews, L, 2003-08-08 02:54:00 [InstanceEdit:75804] Matthews, L, 2003-09-01 04:23:00 [InstanceEdit:157399] Matthews, L, 2004-12-28 18:35:39 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5671755] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:5672773] Orlic-Milacic, Marija, 2015-02-06 [InstanceEdit:5674555] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8985848] Rothfels, Karen, 2017-04-20 [InstanceEdit:9029990] Orlic-Milacic, Marija, 2017-11-23 [InstanceEdit:9632065] Orlic-Milacic, Marija, 2018-12-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of p-S216-CDC25C with 14-3-3 proteins
output	[Complex:75005] p-S216-CDC25C:14-3-3 protein complex [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9029987] p-S216-CDC25C translocates to the cytosol [Homo sapiens] [Reaction:75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 [Homo sapiens] [Reaction:5671749] p-T774-PKN1 phosphorylates CDC25C [Homo sapiens] [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 [Homo sapiens] [Reaction:5671749] p-T774-PKN1 phosphorylates CDC25C [Homo sapiens] [Reaction:5671737] p-T774-PKN1 binds CDC25C [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358420] R-HSA-75016.6
summation	[Summation:75021] CDC25C is phosphorylated by CHK1 at ser-216 (Blasina et al.,...
(hasEvent)	[Pathway:75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex [Homo sapiens] [Pathway:5625740] RHO GTPases activate PKNs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780991] Update Tracker - [Reaction:75016] Association of p-S216-CDC25C with 14-3-3 proteins - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9785472] Update Tracker - [Reaction:75016] Association of p-S216-CDC25C with 14-3-3 proteins - v52:[add_removeInput, modifyText]
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No pathways have been reviewed or authored by Association of p-S216-CDC25C with 14-3-3 proteins (75016)