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Details on Person Phosphorylation of Cdc25C at Ser 216 by Chk1

Class:Id	Reaction:75010
_displayName	Phosphorylation of Cdc25C at Ser 216 by Chk1
_doRelease	TRUE
_timestamp	2025-03-10 15:17:59
authored	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00
catalystActivity	[CatalystActivity:182636] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75002] Matthews, L, 2003-08-05 01:10:00
edited	[InstanceEdit:182637] Matthews, L, 2006-07-10 19:19:59
input	[SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:69741] CDC25C [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:75011] Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. [LiteratureReference:9941611] Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
modified	[InstanceEdit:75804] Matthews, L, 2003-09-01 04:23:00 [InstanceEdit:113707] Matthews, L, 0000-00-00 00:00:00 [InstanceEdit:113750] Schmidt, EE, 2004-06-21 07:42:57 [InstanceEdit:156494] Matthews, L, 2004-11-16 23:13:33 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08 [InstanceEdit:177296] D'Eustachio, P, 2006-03-27 18:48:54 [InstanceEdit:182645] Matthews, L, 2006-07-11 15:34:10 [InstanceEdit:182670] Matthews, L, 2006-07-11 21:36:29 [InstanceEdit:387142] Matthews, L, 2008-12-01 05:48:41 [InstanceEdit:8861951] Orlic-Milacic, Marija, 2016-02-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9635363] Orlic-Milacic, Marija, 2019-01-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941615] Orlic-Milacic, Marija, 2025-03-10
name	Phosphorylation of Cdc25C at Ser 216 by Chk1
output	[SimpleEntity:113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:156496] p-S216-CDC25C [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:176116] Recruitment and activation of Chk1 [Homo sapiens] [Reaction:176298] Activation of claspin [Homo sapiens] [Reaction:176264] Recruitment of the Rad9-Hus1-Rad1 complex to DNA [Homo sapiens] [BlackBoxEvent:6798268] TP53 and E2F4 inhibit CDC25C expression [Homo sapiens] [Reaction:6798282] TP53 and E2F4 bind the CDC25C gene [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360295] R-HSA-75010.6
summation	[Summation:75013] A recombinant human CHEK1 forms a complex with and phosphory...
(hasEvent)	[Pathway:176187] Activation of ATR in response to replication stress [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9029987] p-S216-CDC25C translocates to the cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791700] Update Tracker - [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - v27:[add_removeInput] [_UpdateTracker:9953704] Update Tracker - [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - v93:[modifyText, removeLiteratureReference]
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