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Details on Person Termination of RNA polymerase I transcription is aided by mu...
| Class:Id | Summation:74997 |
|---|---|
| _displayName | Termination of RNA polymerase I transcription is aided by mu... |
| _timestamp | 2026-05-06 18:57:59 |
| created | [InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29 |
| modified | [InstanceEdit:8984379] Duenas, Corina, 2017-04-05 [InstanceEdit:9988348] Rothfels, Karen, 2026-05-06 |
| text | Termination of RNA polymerase I transcription is aided by multiple copies of an 18-base pair sequence element in the non-transcribed spacer downstream of the 28S rRNA coding region. This element, known as the Sal box, is the termination signal for ribosomal gene transcription (reviewed in Girbig et al, 2022). Based on studies in mouse, the Sal box is bound by transcription termination factor 1 (TTF1) (Grummt, 1986; Evers and Grummt, 1995). Mouse Ttf1 has been shown to bind cooperatively to Sal box chromatin to form oligomers that organize rDNA into loops, pausing the RNA polymeraase I complex (Diermeier et al, 2013; Grummt, 1986; Jansa et al, 1988; Smid et al, 1992; reviewed in Girbig et al, 2022). Binding of TTF1 to the Sal box is also influenced by its interaction with TIP5 and potentially other proteins (Nemeth et al, 1994). Template release and dissociation of the enzyme from the DNA is facilitated by the binding of release factor PTRF, also known as CAVIN1 (Jansa et al, 1988; reviewed in Girbig et al, 2022). |
| (summation) | [Reaction:74994] Elongating RNA Polymerase I Transcription Complex pauses at the TTF1:Sal Box [Homo sapiens] |
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