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Details on Person Elongating RNA Polymerase I Transcription Complex pauses at the TTF1:Sal Box

Class:Id	Reaction:74994
_displayName	Elongating RNA Polymerase I Transcription Complex pauses at the TTF1:Sal Box
_doRelease	TRUE
_timestamp	2026-05-14 20:17:43
authored	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
inferredFrom	[Reaction:573369] Ttf1 binds the T0 region (Sal Box) of the rDNA [Mus musculus]
input	[Complex:9988366] elongating RNA Polymerase I complex:45S pre-rRNA gene:pre-rRNA transcript [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:74974] TTF1 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9989056] Gillespie, Marc E, 2026-05-14
literatureReference	[LiteratureReference:9987995] Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases [LiteratureReference:74990] A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination. [LiteratureReference:74988] Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I. [LiteratureReference:5211368] Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites [LiteratureReference:74998] Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. [LiteratureReference:9988340] Limited proteolysis unmasks specific DNA-binding of the murine RNA polymerase I-specific transcription termination factor TTFI [LiteratureReference:5219066] The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5419295] May, Bruce, 2014-05-04 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984379] Duenas, Corina, 2017-04-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988367] Rothfels, Karen, 2026-05-06 [InstanceEdit:9989077] Rothfels, Karen, 2026-05-14
name	Elongating RNA Polymerase I Transcription Complex pauses at the TTF1:Sal Box
output	[Complex:74979] paused RNA Pol I complex:45S pre-rRNA gene:pre-rRNA transcript [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:74986] Elongation of pre-rRNA transcript [Homo sapiens] [Reaction:73769] Loss of RRN3 from RNA Polymerase I promoter escape complex [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361392] R-HSA-74994.4
structureModified	[InstanceEdit:9988367] Rothfels, Karen, 2026-05-06
summation	[Summation:74997] Termination of RNA polymerase I transcription is aided by mu...
(hasEvent)	[Pathway:73863] RNA Polymerase I Transcription Termination [Homo sapiens]
(precedingEvent)	[Reaction:74993] PTRF binds the paused RNA Polymerase I complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781438] Update Tracker - [Reaction:74994] Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box - v61:[addLiteratureReference, modifyText]
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