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Details on Person Dissociation of PTRF:RNA Polymerase I:pre-rRNA complex

Class:Id	Reaction:74992
_displayName	Dissociation of PTRF:RNA Polymerase I:pre-rRNA complex
_doRelease	TRUE
_timestamp	2026-05-14 20:17:40
authored	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:73861] Comai, L, 2003-07-03 17:28:24
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
figure	[Figure:75836] /figures/PolI_txn_term_diss.jpg
input	[Complex:74982] PTRF:paused RNA Pol I complex:45S pre-rRNA gene:pre-rRNA transcript [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9989056] Gillespie, Marc E, 2026-05-14
literatureReference	[LiteratureReference:74998] Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.
modified	[InstanceEdit:75829] Gillespie, ME, 2003-09-02 00:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5419295] May, Bruce, 2014-05-04 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988362] Rothfels, Karen, 2026-05-06 [InstanceEdit:9988380] Rothfels, Karen, 2026-05-06 [InstanceEdit:9989077] Rothfels, Karen, 2026-05-14
name	Dissociation of PTRF:RNA Polymerase I:pre-rRNA complex
output	[EntityWithAccessionedSequence:74981] PTRF [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:74974] TTF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:74978] nascent pre-rRNA transcript [nucleoplasm] [Homo sapiens] [Complex:73859] RNA Polymerase I Holoenzyme [nucleoplasm] [Homo sapiens] [Complex:73694] Ac-SL1:p-UBTF:45S pre-rRNA gene [nucleoplasm] [Homo sapiens] [Complex:109634] TFIIH [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:74993] PTRF binds the paused RNA Polymerase I complex [Homo sapiens] [Reaction:74994] Elongating RNA Polymerase I Transcription Complex pauses at the TTF1:Sal Box [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359071] R-HSA-74992.3
structureModified	[InstanceEdit:9988362] Rothfels, Karen, 2026-05-06 [InstanceEdit:9988380] Rothfels, Karen, 2026-05-06
summation	[Summation:75000] PTRF binds the quaternary complex and mediates the dissociat...
(hasEvent)	[Pathway:73863] RNA Polymerase I Transcription Termination [Homo sapiens]
(precedingEvent)	[Reaction:6790905] Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA [Homo sapiens] [Reaction:6790907] Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides [Homo sapiens] [BlackBoxEvent:6791227] 47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA [Homo sapiens]
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