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Details on Person TTF1 binds to the Sal Box

Class:Id	Reaction:74987
_displayName	TTF1 binds to the Sal Box
_doRelease	TRUE
_timestamp	2026-05-06 19:06:27
authored	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:73861] Comai, L, 2003-07-03 17:28:24
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
figure	[Figure:75832] /figures/PolI_txn_PTRF_TTF.jpg
inferredFrom	[Reaction:573369] Ttf1 binds the T0 region (Sal Box) of the rDNA [Mus musculus]
input	[EntityWithAccessionedSequence:74975] Sal Box [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:74974] TTF1 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:74990] A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination. [LiteratureReference:74988] Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I. [LiteratureReference:9988337] Different domains of the murine RNA polymerase I-specific termination factor mTTF-I serve distinct functions in transcription termination [LiteratureReference:9988340] Limited proteolysis unmasks specific DNA-binding of the murine RNA polymerase I-specific transcription termination factor TTFI [LiteratureReference:5211368] Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites [LiteratureReference:5219066] The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo [LiteratureReference:9987995] Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
modified	[InstanceEdit:75829] Gillespie, ME, 2003-09-02 00:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:3211737] May, B, 2013-03-08 [InstanceEdit:5084121] May, B, 2013-11-08 [InstanceEdit:5211378] May, B, 2013-12-10 [InstanceEdit:5219070] May, B, 2013-12-21 [InstanceEdit:5225700] May, B, 2014-01-08 [InstanceEdit:5332992] May, B, 2014-02-18 [InstanceEdit:8856905] May, Bruce, 2016-02-12 [InstanceEdit:9632715] Gillespie, Marc E, 2018-12-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988367] Rothfels, Karen, 2026-05-06
name	TTF1 binds to the Sal Box
output	[Complex:74977] TTF1:Sal Box [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:74986] Elongation of pre-rRNA transcript [Homo sapiens] [Reaction:73769] Loss of RRN3 from RNA Polymerase I promoter escape complex [Homo sapiens]
releaseDate	2014-03-12
releaseStatus	UPDATED
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18 [InstanceEdit:8856904] Iben, Sebastian, 2016-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358911] R-HSA-74987.4
summation	[Summation:74995] As inferred from mouse cell models, the transcription termin...
(hasEvent)	[Pathway:427389] ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression [Homo sapiens] [Pathway:427413] NoRC negatively regulates rRNA expression [Homo sapiens]
(precedingEvent)	[Reaction:427404] Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene [Homo sapiens] [Reaction:427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA [Homo sapiens]
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No pathways have been reviewed or authored by TTF1 binds to the Sal Box (74987)