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Details on Person Elongation of pre-rRNA transcript
Class:Id Reaction:74986 _displayName Elongation of pre-rRNA transcript _doRelease TRUE _timestamp 2026-05-14 20:17:46 catalystActivity [CatalystActivity:164035] DNA-directed RNA polymerase activity of RNA Polymerase I promoter escape complex:45S pre-rRNA gene [nucleoplasm] compartment [Compartment:350] nucleolus created [InstanceEdit:73861] Comai, L, 2003-07-03 17:28:24 input [SimpleEntity:9757634] NTP [nucleoplasm] [Complex:73717] RNA Polymerase I promoter escape complex:45S pre-rRNA gene [nucleoplasm] [Homo sapiens] internalReviewed [InstanceEdit:9989056] Gillespie, Marc E, 2026-05-14 literatureReference [LiteratureReference:9987995] Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases [LiteratureReference:9006682] Mechanism of RNA polymerase I transcription [LiteratureReference:9988043] The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2 [LiteratureReference:9988034] The N-terminal domain of the A12.2 subunit stimulates RNA polymerase I transcription elongation [LiteratureReference:113798] DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. [LiteratureReference:9987972] RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing [LiteratureReference:9988051] Yeast transcription elongation factor Spt5 associates with RNA polymerase I and RNA polymerase II directly [LiteratureReference:9988040] The Paf1 complex is required for efficient transcription elongation by RNA polymerase I [LiteratureReference:9988012] Structure of RNA polymerase I transcribing ribosomal DNA genes [LiteratureReference:9987960] Pre-18S ribosomal RNA is structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae [LiteratureReference:9988048] Visualization of nucleolar genes [LiteratureReference:9987955] Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates [LiteratureReference:5250641] Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression [LiteratureReference:5250647] The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation [LiteratureReference:5219079] CBX3 regulates efficient RNA processing genome-wide [LiteratureReference:9987932] PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis modified [InstanceEdit:75829] Gillespie, ME, 2003-09-02 00:00:00 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:164036] Gillespie, ME, 2005-05-10 20:52:53 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9006684] Gillespie, Marc E, 2017-05-17 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9632715] Gillespie, Marc E, 2018-12-20 [InstanceEdit:9757786] D'Eustachio, Peter, 2021-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988367] Rothfels, Karen, 2026-05-06 [InstanceEdit:9989077] Rothfels, Karen, 2026-05-14 name Elongation of pre-rRNA transcript output [Complex:9988366] elongating RNA Polymerase I complex:45S pre-rRNA gene:pre-rRNA transcript [nucleoplasm] [Homo sapiens] precedingEvent
previousReviewStatus [ReviewStatus:9821384] two stars regulatedBy [PositiveGeneExpressionRegulation:427361] Positive gene expression regulation by 'Chromatin (H3K9me2):CBX3 [nucleoplasm]' [NegativeGeneExpressionRegulation:9988351] Negative gene expression regulation by 'UBTF:PHF6 [nucleoplasm]' regulationReference [RegulationReference:9988350] Negative gene expression regulation by 'UBTF:PHF6 [nucleoplasm]' PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis [RegulationReference:9988355] Positive regulation by 'Chromatin (H3K9me2):CBX3 [nucleoplasm]' CBX3 regulates efficient RNA processing genome-wide releaseDate 2004-07-06 reviewStatus [ReviewStatus:9821385] four stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:360950] R-HSA-74986.7 structureModified [InstanceEdit:9988367] Rothfels, Karen, 2026-05-06 summation [Summation:178700] After promoter clearance and transcriptional initiation, RNA... (hasEvent) [Pathway:73772] RNA Polymerase I Promoter Escape [Homo sapiens] (inferredFrom) [Reaction:1113253] Elongation of pre-rRNA transcript [Oryza sativa] (orthologousEvent) [Reaction:1113253] Elongation of pre-rRNA transcript [Oryza sativa] (precedingEvent) [Reaction:74987] TTF1 binds to the Sal Box [Homo sapiens] [Reaction:74994] Elongating RNA Polymerase I Transcription Complex pauses at the TTF1:Sal Box [Homo sapiens] (updatedInstance) [_UpdateTracker:9775468] Update Tracker - [Reaction:74986] Elongation of pre-rRNA transcript - v79:[add_removeInput] [_UpdateTracker:9781376] Update Tracker - [Reaction:74986] Elongation of pre-rRNA transcript - v61:[addLiteratureReference] [_UpdateTracker:9791381] Update Tracker - [Reaction:74986] Elongation of pre-rRNA transcript - v30:[addRegulator]
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