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Details on Person UniProt:Q15361 TTF1

Class:IdReferenceGeneProduct:74973
_chainChangeLogchain:1-905 added on Fri February 6 2015
_displayNameUniProt:Q15361 TTF1
_timestamp2024-11-03 20:08:16
chainchain:1-905
checksum12F829CEFDDF96E8
commentFUNCTION Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.SUBUNIT Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments. Interacts with BAZ2A/TIP5. Interacts with CAVIN1. Interacts (via the N-terminal region (NRD) and a C-terminal region) with CDKN2A/ARF; the interaction is direct. Interacts (via C-terminal region) with NPM1/B23.SUBCELLULAR LOCATION May be localized to the nucleolus in an NPM1/B23-dependent manner. May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner. May shuttle back and forth from nucleoplasm to nucleolus.DOMAIN The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the C-terminal part.
created[InstanceEdit:74972] Gillespie, ME, 2003-07-30 00:00:00
descriptionrecommendedName: Transcription termination factor 1 shortName: TTF-1 alternativeName: RNA polymerase I termination factor alternativeName: Transcription termination factor I shortName: TTF-I
geneNameTTF1
identifierQ15361
isSequenceChangedFALSE
keywordDNA replication inhibitor
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transcription
Transcription regulation
Transcription termination
Ubl conjugation
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameTTF1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9000930] ENSEMBL:ENSG00000125482 TTF1 [Homo sapiens]
secondaryIdentifierTTF1_HUMAN
A1L160
Q4VXF3
Q58EY2
Q6P5T5
sequenceLength905
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:74974] TTF1 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q15361 TTF1 (74973)
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