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Details on Person PP2A dephosphorylates p-RHO to RHO

Class:Id	Reaction:74948
_displayName	PP2A dephosphorylates p-RHO to RHO
_doRelease	TRUE
_timestamp	2014-06-30 10:14:53
authored	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
catalystActivity	[CatalystActivity:142098] protein serine/threonine phosphatase activity of PPEF1:Mg2+ [cytosol]
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
edited	[InstanceEdit:2632520] Jassal, Bijay, 2012-11-21
input	[EntityWithAccessionedSequence:2581504] p-S334,338,343-RHO [photoreceptor disc membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:2632511] Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC) [LiteratureReference:75393] Interplay of phosphorylation and dephosphorylation in vision: protein phosphatases of bovine rod outer segments. [LiteratureReference:3262427] Calcium-activated opsin phosphatase activity in retinal rod outer segments [LiteratureReference:75392] The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. [LiteratureReference:74648] Regulation of rhodopsin dephosphorylation by arrestin. [LiteratureReference:3262439] Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2) [LiteratureReference:74644] The sequence of human retinal S-antigen reveals similarities with alpha-transducin.
modified	[InstanceEdit:74964] Schmidt, EE, 2003-07-31 08:44:50 [InstanceEdit:75321] Schmidt, EE, 2003-09-01 06:01:22 [InstanceEdit:75401] Schmidt, EE, 2003-09-01 09:25:45 [InstanceEdit:74153] Schmidt, EE, 2003-07-15 11:28:00 [InstanceEdit:142099] Schmidt, EE, 2004-11-08 14:00:58 [InstanceEdit:2470272] Jassal, Bijay, 2012-09-18 [InstanceEdit:2632502] Jassal, Bijay, 2012-11-21 [InstanceEdit:3262437] Jassal, Bijay, 2013-04-10 [InstanceEdit:3270611] Jassal, Bijay, 2013-04-11 [InstanceEdit:3632877] Jassal, Bijay, 2013-05-28 [InstanceEdit:5603172] Jassal, Bijay, 2014-06-30 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PP2A dephosphorylates p-RHO to RHO
output	[SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [EntityWithAccessionedSequence:419802] RHO [photoreceptor disc membrane] [Homo sapiens]
precedingEvent	[Reaction:74947] p-MII:SAG dissociates to p-RHO and SAG [Homo sapiens] [Reaction:2632521] at-retinyl is hydrolysed from p-MII:SAG to release atRAL [Homo sapiens]
regulatedBy	[PositiveRegulation:2648999] Positive regulation by 'Ca2+ [cytosol]' [NegativeRegulation:5603164] Negative regulation by 'p-MII:SAG [photoreceptor disc membrane]'
releaseDate	2013-06-11
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654383] R-HSA-74948.3
summation	[Summation:2632501] Protein phosphatase 2A removes the phosphates from phosphory...
(hasEvent)	[Pathway:74949] Rhodopsin regeneration [Homo sapiens] [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade [Homo sapiens]
(precedingEvent)	[Reaction:2454118] 11cRAL binds to opsin to form 11c-retinyl:RHO [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786142] Update Tracker - [Reaction:74948] PP2A dephosphorylates p-RHO to RHO - v50:[addLiteratureReference, add_removeRegulator, modifyText]
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