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Details on Person The Ligand:GPCR:Gi complex dissociates

Class:Id	Reaction:749454
_displayName	The Ligand:GPCR:Gi complex dissociates
_doRelease	TRUE
_timestamp	2020-05-19 13:14:17
authored	[InstanceEdit:744889] Jupe, S, 2010-05-18
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:749449] Jupe, S, 2010-05-18
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[Complex:749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified	[InstanceEdit:749459] Jupe, S, 2010-05-18 [InstanceEdit:790905] Jupe, S, 2010-05-24 [InstanceEdit:804958] Jupe, S, 2010-05-26 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:817606] Jupe, S, 2010-05-26 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8964250] Varusai, Thawfeek, 2017-02-16 [InstanceEdit:8982644] Varusai, Thawfeek, 2017-03-21 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9673431] Murillo, Julieth, 2020-01-07 [InstanceEdit:9689422] Jassal, Bijay, 2020-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The Ligand:GPCR:Gi complex dissociates
output	[Complex:392161] G alpha (i): GTP [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [DefinedSet:380091] Ligand:GPCR complexes that activate Gi [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:380073] Liganded Gi-activating GPCR acts as a GEF for Gi [Homo sapiens] [Reaction:749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105064] R-HSA-749454.6
summation	[Summation:804955] The classical view of G-protein signalling is that the G-pro...
(hasEvent)	[Pathway:418594] G alpha (i) signalling events [Homo sapiens] [Pathway:9664309] C3AR1 mediated IL6 production [Homo sapiens] [Pathway:9665567] C3AR1 mediated synthesis of pro-inflammatory cytokines [Homo sapiens]
(precedingEvent)	[Reaction:392206] G alpha (i) inhibits adenylate cyclase [Homo sapiens] [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] [Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens] [Reaction:8964311] G alpha (i):GTP binds SRC [Homo sapiens] [Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens] [Reaction:8978882] G-protein beta-gamma complex binds to voltage-gated calcium channel [Homo sapiens] List all 11 refering instances
(updatedInstance)	[_UpdateTracker:9776975] Update Tracker - [Reaction:749454] The Ligand:GPCR:Gi complex dissociates - v73:[add_removeOutput]
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No pathways have been reviewed or authored by The Ligand:GPCR:Gi complex dissociates (749454)