Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq

Class:Id	Reaction:749448
_displayName	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
_doRelease	TRUE
_timestamp	2018-08-02 09:02:20
authored	[InstanceEdit:745612] Jupe, S, 2010-05-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:749449] Jupe, S, 2010-05-18
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[DefinedSet:380110] Ligand:GPCR complexes that activate Gq/11 [plasma membrane] [Homo sapiens] [Complex:114557] Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:383358] Stable association between G alpha(q) and phospholipase C beta 1 in living cells
modified	[InstanceEdit:749459] Jupe, S, 2010-05-18 [InstanceEdit:751025] Jupe, S, 2010-05-19 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:947661] Jupe, S, 2010-09-10 [InstanceEdit:981833] Jupe, S, 2010-10-28 [InstanceEdit:2105026] Jassal, Bijay, 2012-02-09 [InstanceEdit:3222584] Jupe, S, 2013-03-25 [InstanceEdit:8983501] Varusai, Thawfeek, 2017-03-24 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9024676] Jupe, Steve, 2017-10-06 [InstanceEdit:9615353] Jassal, Bijay, 2018-08-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
output	[Complex:749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:374173] AGT(25-32) binds to AGTR1 [Homo sapiens] [Reaction:2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:9615348] AGT(25-32) binds to AGTR2 [Homo sapiens] [Reaction:2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:375384] Bombesin-like receptors bind bombesin homologues [Homo sapiens] [Reaction:374331] Bradykinin receptors B1 and B2 bind to bradykinin [Homo sapiens] [Reaction:390649] CHRM1,3,5 bind acetylcholine [Homo sapiens] [Reaction:390930] 5-HT2 receptor can bind serotonin [Homo sapiens] [Reaction:390641] ADRA1A,B,D bind ADR,NAd [Homo sapiens] [Reaction:9623384] α1-agonists bind ADRA1A,B,D [Homo sapiens] [Reaction:390912] HRH1 binds hist [Homo sapiens] [Reaction:391372] GNRHR binds GNRH1,2 [Homo sapiens] [Reaction:388468] AVP(20-28) binds AVPR1A,B [Homo sapiens] [Reaction:417908] P2RY1 binds ADP [Homo sapiens] [Reaction:417927] P2Y2 receptor binds ATP and UTP [Homo sapiens] [Reaction:417890] P2Y5 receptor can bind to LPA [Homo sapiens] [Reaction:417896] P2Y6 receptor can bind to UDP [Homo sapiens] [Reaction:417842] P2Y10 receptor can bind to LPA [Homo sapiens] [Reaction:417820] P2Y9 receptor can bind to LPA [Homo sapiens] [Reaction:163625] Glucagon binds to Glucagon receptor [Homo sapiens] [Reaction:419861] Melanospin is stimulated by light [Homo sapiens] [Reaction:420724] CASR binds Ca2+ [Homo sapiens] [Reaction:444208] MLNR (GPR38) is a receptor for motilin [Homo sapiens] [Reaction:444498] Thyrotropin-releasing hormone receptor binds thyrotropin [Homo sapiens] [Reaction:444620] Neuropeptide S receptor binds neuropeptide S [Homo sapiens] [Reaction:444691] Prokineticin receptors bind prokineticin [Homo sapiens] [Reaction:444202] Receptor FFAR1 binds free fatty acids [Homo sapiens] [Reaction:444171] Receptor FFAR2 binds carboxylates [Homo sapiens] [Reaction:444047] Receptor FFAR3 binds carboxylates [Homo sapiens] [Reaction:445113] Urotensin-2 receptor binds urotensin-2 and 2B [Homo sapiens] [Reaction:444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors [Homo sapiens] [Reaction:947647] GHSR is a receptor for ghrelin [Homo sapiens] [BlackBoxEvent:422048] Acyl Ghrelin and C-Ghrelin are secreted [Homo sapiens] [Reaction:981832] NMUR2 binds neuromedin-S [Homo sapiens] [Reaction:964800] Neuromedin-U receptors bind neuromedins U, S [Homo sapiens] [Reaction:870269] Gastrin binds to CCK-B receptor [Homo sapiens] [Reaction:373075] Metabotropic glutamate receptors bind glutamate [Homo sapiens] [Reaction:444191] GPR120 is a receptor for unsaturated long-chain free fatty acids [Homo sapiens] [Reaction:444572] Zinc is an agonist of GPR39 [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105196] R-HSA-749448.5
summation	[Summation:751020] Numerous functionally unrelated GPCRs couple with the Gq G-p...
(hasEvent)	[Pathway:416476] G alpha (q) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 [Homo sapiens] [Reaction:9664326] Activation of Gq/11 [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (749448)