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Details on Person Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz

Class:Id	Reaction:749446
_displayName	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
_doRelease	TRUE
_timestamp	2017-07-11 09:40:07
authored	[InstanceEdit:745612] Jupe, S, 2010-05-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:749449] Jupe, S, 2010-05-18
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[Complex:391985] Heterotrimeric G-protein Gz (inactive) [plasma membrane] [Homo sapiens] [Complex:390700] ADRA2A,B,C:ADR,NAd [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:435188] G(z) signaling: emerging divergence from G(i) signaling [LiteratureReference:428076] Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
modified	[InstanceEdit:749459] Jupe, S, 2010-05-18 [InstanceEdit:751025] Jupe, S, 2010-05-19 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:833616] Jupe, S, 2010-05-27 [InstanceEdit:8944095] Jupe, Steve, 2016-11-02 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
output	[Complex:749450] Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:390663] ADRA2A,B,C bind ADR,NAd [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105662] R-HSA-749446.4
summation	[Summation:751005] Gz is predominantly expressed in the nervous system and plat...
(hasEvent)	[Pathway:418597] G alpha (z) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:749453] Liganded Gz-activating GPCR acts as a GEF for Gz [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782323] Update Tracker - [Reaction:749446] Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz - v59:[add_removeInput]
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No pathways have been reviewed or authored by Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (749446)