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Details on Person UniProt:P51177 GUCA1B
| Class:Id | ReferenceGeneProduct:74912 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-204 added on Sat February 7 2015;initiator methionine:1 for 74912 removed on Fri Nov 03 2023;initiator methionine: for 74912 added on Fri Nov 03 2023;initiator methionine: for 74912 removed on Fri Aug 15 2025;initiator methionine:1 for 74912 added on Fri Aug 15 2025 |
| _displayName | UniProt:P51177 GUCA1B |
| _timestamp | 2025-08-15 22:08:25 |
| chain | initiator methionine:1 chain:2-204 |
| checksum | BA375D54960E5F75 |
| comment | FUNCTION Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (PubMed:7665624). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:9651312). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).SUBCELLULAR LOCATION Subcellular location is not affected by light or dark conditions.TISSUE SPECIFICITY In the retina, expressed in rod and cone photoreceptor cells. Appears to be more abundant in rods.PTM The N-terminus is blocked.MISCELLANEOUS Binds three calcium ions. |
| description | recommendedName: Guanylyl cyclase-activating protein 2 shortName: GCAP 2 alternativeName: Guanylate cyclase activator 1B alternativeName: Retinal guanylyl cyclase activator protein p24 |
| geneName | GUCA1B GCAP-2 GCAP2 |
| identifier | P51177 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell membrane Cell projection Direct protein sequencing Lipoprotein Membrane Metal-binding Myristate Reference proteome Repeat Sensory transduction Vision |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GUCA1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GUC1B_BOVIN |
| sequenceLength | 204 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:74913] GCAP2 [cytosol] [Bos taurus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P51177 GUCA1B (74912)
