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Details on Person GUCYs converts GTP to cGMP

Class:Id	Reaction:74885
_displayName	GUCYs converts GTP to cGMP
_doRelease	TRUE
_timestamp	2013-05-31 09:50:28
authored	[InstanceEdit:74470] Carleton, KL, 2003-07-22 11:02:31
catalystActivity	[CatalystActivity:74884] guanylate cyclase activity of GUCYs [photoreceptor disc membrane]
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
edited	[InstanceEdit:2648981] Jassal, Bijay, 2012-11-22
input	[SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:74892] Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. [LiteratureReference:2586756] Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily [LiteratureReference:2586746] The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1) [LiteratureReference:75335] Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. [LiteratureReference:74890] Molecular cloning of a retina-specific membrane guanylyl cyclase.
modified	[InstanceEdit:74920] Schmidt, EE, 2003-07-30 11:40:34 [InstanceEdit:74964] Schmidt, EE, 2003-07-31 08:44:50 [InstanceEdit:75321] Schmidt, EE, 2003-09-01 06:01:22 [InstanceEdit:2470272] Jassal, Bijay, 2012-09-18 [InstanceEdit:2586730] Jassal, Bijay, 2012-11-16 [InstanceEdit:2586753] Jassal, Bijay, 2012-11-16 [InstanceEdit:2648981] Jassal, Bijay, 2012-11-22 [InstanceEdit:3229194] Jassal, Bijay, 2013-03-26 [InstanceEdit:3270611] Jassal, Bijay, 2013-04-11 [InstanceEdit:3632877] Jassal, Bijay, 2013-05-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GUCYs converts GTP to cGMP cGMP synthesis by guanylyl cyclase
output	[SimpleEntity:30991] cGMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
regulatedBy	[NegativeRegulation:2586745] Negative regulation by 'GUCA:Ca2+ [photoreceptor disc membrane]' [PositiveRegulation:9034480] Positive regulation by 'GUCA1B [cytosol]' [PositiveRegulation:9034482] Positive regulation by 'GUCA1A [cytosol]' [NegativeRegulation:9034483] Negative regulation by 'GCAP1:Ca2+ [cytosol]' [NegativeRegulation:9034486] Negative regulation by 'GCAP2:Ca2+ [cytosol]'
releaseDate	2013-06-11
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654540] R-HSA-74885.3
summation	[Summation:74889] The basal, "dark" levels of cGMP are restored as part of the...
(hasEvent)	[Pathway:74904] Recovery [Homo sapiens] [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade [Homo sapiens]
(precedingEvent)	[Reaction:74031] cGMP binds CNG channel to form cGMP:CNG channel [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779971] Update Tracker - [Reaction:74885] GUCYs converts GTP to cGMP - v64:[addRegulator] [_UpdateTracker:9786811] Update Tracker - [Reaction:74885] GUCYs converts GTP to cGMP - v48:[removeRegulator]
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