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Details on Person PIK3R1 [cytosol]
Class:Id EntityWithAccessionedSequence:74789
_displayName PIK3R1 [cytosol]
_timestamp 2014-09-26 07:14:56
compartment [Compartment:70101] cytosol
created [InstanceEdit:74677] Schmidt, EE, 2003-08-20 08:52:29
endCoordinate 724
modified [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:1295755] Jupe, S, 2011-05-18 [InstanceEdit:1302655] Jupe, S, 2011-05-27 [InstanceEdit:1927284] Williams, MG, 2011-11-02 [InstanceEdit:5624358] Jupe, Steve, 2014-09-26
name PIK3R1 PI3K p85 alpha Phosphatidylinositol 3-kinase regulatory alpha subunit PI3-kinase p85-alpha subunit PtdIns-3-kinase p85-alpha
referenceEntity [ReferenceGeneProduct:61192] UniProt:P27986 PIK3R1 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:370476] R-HSA-74789.1
startCoordinate 1
(hasCandidate) [CandidateSet:1295511] PI3K regulatory subunits [cytosol] [Homo sapiens] [CandidateSet:8981636] RHOA GAPs [cytosol] [Homo sapiens] [CandidateSet:9013040] RHOB GAPs [cytosol] [Homo sapiens] [CandidateSet:9013126] RHOC GAPs [cytosol] [Homo sapiens] [CandidateSet:9013175] RAC1 GAPs [cytosol] [Homo sapiens] [CandidateSet:9013234] CDC42 GAPs [cytosol] [Homo sapiens] [CandidateSet:9013450] RHOD GAPs [cytosol] [Homo sapiens] [CandidateSet:9014408] RAC2 GAPs [cytosol] [Homo sapiens] [CandidateSet:9014436] RHOG GAPs [cytosol] [Homo sapiens] [CandidateSet:9017487] RHOJ GAPs [cytosol] [Homo sapiens]
(hasComponent) [Complex:179864] GRB2:GAB1:PIK3R1 [cytosol] [Homo sapiens] [Complex:204878] phosphorylated Axl and p85 complex [plasma membrane] [Homo sapiens] [Complex:205230] Sky : p85 complex [plasma membrane] [Homo sapiens] [Complex:443399] GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] [Homo sapiens] [Complex:1806184] PIK3CB:PIK3R1 [cytosol] [Homo sapiens] [Complex:1806213] PIK3CD:PIK3R1 [cytosol] [Homo sapiens] [Complex:1806218] PIK3CA:PIK3R1 [cytosol] [Homo sapiens] [Complex:1839048] p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol] [Homo sapiens] [Complex:1839052] p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol] [Homo sapiens] [Complex:9607223] Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] [Homo sapiens]
(hasMember) [DefinedSet:74688] PI3K-regulatory subunit [cytosol] [Homo sapiens] [CandidateSet:391342] PI3K-regulatory subunits [cytosol] [Homo sapiens] [DefinedSet:6790032] STAT3-upregulated cytosolic proteins [cytosol] [Homo sapiens] [CandidateSet:9019558] RHOU effectors [cytosol] [Homo sapiens]
(input) [Reaction:177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 [Homo sapiens] [Reaction:205274] Interaction of Sky and p85-PI3K [Homo sapiens] [Reaction:443402] GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K [Homo sapiens] [BlackBoxEvent:1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 [Homo sapiens] [Reaction:1839114] BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 [Homo sapiens] [Reaction:9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 [Homo sapiens] [Reaction:9698179] FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 [Homo sapiens] [Reaction:9703439] FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 [Homo sapiens] [Reaction:9706340] Active FLT3:p-Y-GRB10 binds PIK3R1 [Homo sapiens] [BlackBoxEvent:9712078] ALK mutants bind PI3KR1 [Homo sapiens]
(regulator) [Requirement:9945932] Requirement by 'PIK3R1 [cytosol]'
(updatedInstance) [_UpdateTracker:9870171] Update Tracker - [EntityWithAccessionedSequence:74789] PIK3R1 [cytosol] - v37:[modifyName] [_UpdateTracker:9871106] Update Tracker - [EntityWithAccessionedSequence:74789] PIK3R1 [cytosol] - v39:[modifyEndCoordinate]
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Pathways
No pathways have been reviewed or authored by PIK3R1 [cytosol] (74789)