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Details on Person PIK3CA [cytosol]

Class:Id	EntityWithAccessionedSequence:74787
_displayName	PIK3CA [cytosol]
_timestamp	2011-11-02 16:41:10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74677] Schmidt, EE, 2003-08-20 08:52:29
endCoordinate	1068
modified	[InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:941603] Jupe, S, 2010-09-03 [InstanceEdit:1474193] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1500921] Orlic-Milacic, Marija, 2011-08-22 [InstanceEdit:1927284] Williams, MG, 2011-11-02
name	PIK3CA PI3K-p110 PI3-kinase p110 subunit alpha Phosphatidylinositol 3-kinase catalytic subunit, alpha isoform (EC 2.7.1.137) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform PtdIns- 3-kinase p110
referenceEntity	[ReferenceGeneProduct:61074] UniProt:P42336 PIK3CA [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:363065] R-HSA-74787.1
startCoordinate	1
(activeUnit)	[CatalystActivity:179881] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] [CatalystActivity:186820] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] [CatalystActivity:202288] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K bound to TRAT [plasma membrane] [CatalystActivity:1839104] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol] [CatalystActivity:1986642] kinase activity of Activated FGFR mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:5655254] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:5655273] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:5655329] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [CatalystActivity:5655340] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(hasComponent)	[Complex:198379] PI3K alpha [cytosol] [Homo sapiens] [Complex:1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] [Homo sapiens] [Complex:1268234] Activated FGFR:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens] [Complex:1268236] Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens] [Complex:1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens] [Complex:1806182] PIK3CA:PIK3R3 [cytosol] [Homo sapiens] [Complex:1806218] PIK3CA:PIK3R1 [cytosol] [Homo sapiens] [Complex:1806270] PIK3CA:PIK3R2 [cytosol] [Homo sapiens] [Complex:1839051] pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol] [Homo sapiens] [Complex:1839055] p-FGFR1 mutant fusions:PI3K [cytosol] [Homo sapiens] List all 33 refering instances
(hasMember)	[DefinedSet:74689] PI3K-catalytic subunit [cytosol] [Homo sapiens] [DefinedSet:1806293] PIK3CA/B/D [cytosol] [Homo sapiens]
(input)	[Reaction:1839080] Activated cytosolic FGFR1 fusions bind PIK3CA [Homo sapiens] [Reaction:1839102] BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA [Homo sapiens] [Reaction:5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens] [Reaction:5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens] [Reaction:5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens] [Reaction:5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA [Homo sapiens] [Reaction:5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA [Homo sapiens] List all 19 refering instances
(updatedInstance)	[_UpdateTracker:9870663] Update Tracker - [EntityWithAccessionedSequence:74787] PIK3CA [cytosol] - v38:[addName] [_UpdateTracker:9871360] Update Tracker - [EntityWithAccessionedSequence:74787] PIK3CA [cytosol] - v39:[modifyEndCoordinate]
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No pathways have been reviewed or authored by PIK3CA [cytosol] (74787)