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Details on Person Endosomal protein tyrosine phosphatases (PTPs) dephosphoryla...
| Class:Id | Summation:74754 |
|---|---|
| _displayName | Endosomal protein tyrosine phosphatases (PTPs) dephosphoryla... |
| _timestamp | 2022-08-30 17:14:27 |
| created | [InstanceEdit:74816] 2003-07-28 10:05:14 |
| modified | [InstanceEdit:74806] Schmidt, EE, 2003-07-28 08:28:53 [InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13 [InstanceEdit:75843] Schmidt, EE, 2003-09-08 06:32:26 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 [InstanceEdit:77420] Schmidt, EE, 2003-10-27 06:13:17 [InstanceEdit:9609398] D'Eustachio, Peter, 2018-05-23 [InstanceEdit:9815890] D'Eustachio, Peter, 2022-08-30 |
| text | Endosomal protein tyrosine phosphatases (PTPs) dephosphorylate the insulin receptor, which cannot rephosphorylate itself as insulin is removed leaving the receptor in its inactive conformation (Bevan et al. 1996; Drake & Posner 1998). The identity of these PTPs is not definitively established, but structural studies and studies of cell lines and gene-knockout mice indicate that PTPRF / LAR (Ahmed & Goldstein 1997) and PTPN1 / PTP1B (Li et al. 2005) are each capable of mediating this reaction. The dephosphorylated receptor recycles to the plasma membrane. |
| (summation) | [Reaction:74733] Insulin receptor de-phosphorylation [Homo sapiens] |
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No pathways have been reviewed or authored by Endosomal protein tyrosine phosphatases (PTPs) dephosphoryla... (74754)
