Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person De-phosphorylation of p-Y427-SHC1

Class:Id	BlackBoxEvent:74748
_displayName	De-phosphorylation of p-Y427-SHC1
_doRelease	TRUE
_timestamp	2024-03-20 22:00:38
catalystActivity	[CatalystActivity:74732] protein tyrosine phosphatase activity of protein tyrosine phosphatase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[EntityWithAccessionedSequence:74684] p-Y427-SHC1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:8984404] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner [LiteratureReference:8984407] Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding [LiteratureReference:8984387] Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
modified	[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:75846] Schmidt, EE, 2003-09-08 11:39:12 [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5686055] Jupe, Steve, 2015-03-31 [InstanceEdit:5686325] Jupe, Steve, 2015-04-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984457] Duenas, Corina, 2017-04-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
name	De-phosphorylation of p-Y427-SHC1
negativePrecedingEvent	[NegativePrecedingEvent:9865952] Futile Cycle: GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates
output	[EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:74743] Dissociation of p-Y427-SHC1 from insulin receptor [Homo sapiens] [Reaction:74742] Phosphorylation of SHC1 [Homo sapiens]
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361601] R-HSA-74748.5
summation	[Summation:178643] At the beginning of this reaction, 1 molecule of 'phospho-SH...
(hasEvent)	[Pathway:74749] Signal attenuation [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9865955] Futile Cycle: De-phosphorylation of p-Y427-SHC1
(updatedInstance)	[_UpdateTracker:9780924] Update Tracker - [BlackBoxEvent:74748] De-phosphorylation of p-Y427-SHC1 - v61:[addLiteratureReference, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by De-phosphorylation of p-Y427-SHC1 (74748)