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Details on Person GRB2-1:SOS1 binds p-Y427-SHC1

Class:IdReaction:74746
_displayNameGRB2-1:SOS1 binds p-Y427-SHC1
_doReleaseTRUE
_timestamp2024-03-20 22:00:51
authored[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
compartment[Compartment:70101] cytosol
created[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
edited[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
figure[Figure:157815] /figures/Grb2_SHC.jpg
input[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:74684] p-Y427-SHC1 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:110025] Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
modified[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54
[InstanceEdit:75846] Schmidt, EE, 2003-09-08 11:39:12
[InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24
[InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23
[InstanceEdit:77420] Schmidt, EE, 2003-10-27 06:13:17
[InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12
[InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30
[InstanceEdit:159389] Schmidt, EE, 2005-03-08 11:44:29
[InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07
[InstanceEdit:188324] Jassal, Bijay, 2006-10-06
[InstanceEdit:188949] Gopinathrao, G, 2006-10-31 12:06:45
[InstanceEdit:189835] Jassal, Bijay, 2006-12-07
[InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44
[InstanceEdit:204298] Jassal, Bijay, 2007-11-28
[InstanceEdit:443903] Jupe, S, 2009-10-16
[InstanceEdit:535706] Jassal, B, 2010-03-04
[InstanceEdit:1806830] Jassal, Bijay, 2011-10-24
[InstanceEdit:2453745] May, B, 2012-08-15
[InstanceEdit:2453799] May, B, 2012-08-16
[InstanceEdit:5624357] Jupe, Steve, 2014-09-25
[InstanceEdit:5685348] Jupe, Steve, 2015-03-27
[InstanceEdit:5685364] Jupe, Steve, 2015-03-27
[InstanceEdit:5686058] Jupe, Steve, 2015-03-31
[InstanceEdit:9030422] Rothfels, Karen, 2017-11-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
nameGRB2-1:SOS1 binds p-Y427-SHC1
negativePrecedingEvent[NegativePrecedingEvent:9865961] Futile Cycle: GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates
output[Complex:109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2007-12-11
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360183] R-HSA-74746.4
summation[Summation:77421] Tyrosine-phosphorylated SHC1 recruits the SH2 domain of the ...
(hasEvent)[Pathway:74751] Insulin receptor signalling cascade [Homo sapiens]
(precedingEvent)[Reaction:109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS [Homo sapiens]
[Reaction:109822] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 [Homo sapiens]
[Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784629] Update Tracker - [Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 - v53:[add_removeInput, modifyText]
[_UpdateTracker:9790364] Update Tracker - [Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 - v33:[add_removeInput]
[_UpdateTracker:9792511] Update Tracker - [Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 - v20:[modifyText]
[_UpdateTracker:9939639] Update Tracker - [Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 - v92:[modifyText]
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No pathways have been reviewed or authored by GRB2-1:SOS1 binds p-Y427-SHC1 (74746)
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