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Details on Person Phosphorylation of SHC1

Class:Id	Reaction:74742
_displayName	Phosphorylation of SHC1
_doRelease	TRUE
_timestamp	2017-04-06 15:47:59
catalystActivity	[CatalystActivity:74741] transmembrane receptor protein tyrosine kinase activity of Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane]
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[Complex:74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:5685352] The functional significance of Shc in insulin signaling as a substrate of the insulin receptor [LiteratureReference:8984404] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner
modified	[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:113846] Schmidt, EE, 2004-06-23 11:28:38 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5685348] Jupe, Steve, 2015-03-27 [InstanceEdit:5685364] Jupe, Steve, 2015-03-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01 [InstanceEdit:8984457] Duenas, Corina, 2017-04-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of SHC1
output	[Complex:74685] Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:74740] Binding of SHC1 to insulin receptor [Homo sapiens] [Reaction:74715] Autophosphorylation of insulin receptor [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360362] R-HSA-74742.5
summation	[Summation:179079] SHC1 is tyrosine phosphorylated at Tyr-427 by the insulin re...
(hasEvent)	[Pathway:74751] Insulin receptor signalling cascade [Homo sapiens]
(precedingEvent)	[Reaction:74743] Dissociation of p-Y427-SHC1 from insulin receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781019] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9784832] Update Tracker - [Reaction:74742] Phosphorylation of SHC1 - v53:[addLiteratureReference, modifyText]
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