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Details on Person Binding of SHC1 to insulin receptor

Class:Id	Reaction:74740
_displayName	Binding of SHC1 to insulin receptor
_doRelease	TRUE
_timestamp	2024-03-20 22:00:35
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[Complex:74678] Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:8984437] Insulin receptor substrate-1 enhances growth hormone-induced proliferation [LiteratureReference:8984404] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner
modified	[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:113846] Schmidt, EE, 2004-06-23 11:28:38 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5624357] Jupe, Steve, 2014-09-25 [InstanceEdit:5685348] Jupe, Steve, 2015-03-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984457] Duenas, Corina, 2017-04-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
name	Binding of SHC1 to insulin receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865955] Futile Cycle: De-phosphorylation of p-Y427-SHC1 [NegativePrecedingEvent:9865956] Futile Cycle: Dissociation of IRS-P from insulin receptor [NegativePrecedingEvent:9865960] Futile Cycle: Dissociation of p-Y427-SHC1 from insulin receptor
output	[Complex:74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:74715] Autophosphorylation of insulin receptor [Homo sapiens] [Reaction:74716] Insulin binds the insulin receptor [Homo sapiens]
regulatedBy	[NegativeRegulation:110031] Negative regulation by 'GRB10:INSR [plasma membrane]'
regulationReference	[RegulationReference:9641227] Negative regulation by 'GRB10:INSR [plasma membrane]' Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361551] R-HSA-74740.7
summation	[Summation:74745] SHC1 interacts via its SH2 domain with the carboxyterminal p...
(hasEvent)	[Pathway:74751] Insulin receptor signalling cascade [Homo sapiens]
(precedingEvent)	[Reaction:74742] Phosphorylation of SHC1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781213] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9784808] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v53:[add_removeSummation] [_UpdateTracker:9786120] Update Tracker - [Reaction:74740] Binding of SHC1 to insulin receptor - v50:[add_removeRegulator]
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