Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person IRS1, IRS2 and IRS3 are all known to bind the regulatory sub...

Class:IdSummation:74739
_displayNameIRS1, IRS2 and IRS3 are all known to bind the regulatory sub...
_timestamp2017-04-05 15:28:48
created[InstanceEdit:74816] 2003-07-28 10:05:14
literatureReference[LiteratureReference:8984312] Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
modified[InstanceEdit:74806] Schmidt, EE, 2003-07-28 08:28:53
[InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13
[InstanceEdit:77420] Schmidt, EE, 2003-10-27 06:13:17
[InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30
[InstanceEdit:157835] Schmidt, EE, 2005-01-07 14:38:14
[InstanceEdit:8984379] Duenas, Corina, 2017-04-05
textIRS1, IRS2 and IRS3 are all known to bind the regulatory subunit of PI3K via its SH2 domain, an interaction that itself activates the kinase activity of the PI3K catalytic subunit (Rivachandran et al. 2001).
(summation)[Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K [Homo sapiens]
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No pathways have been reviewed or authored by IRS1, IRS2 and IRS3 are all known to bind the regulatory sub... (74739)