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Details on Person p-Y-IRS1,p-Y-IRS2 bind PI3K

Class:Id	Reaction:74737
_displayName	p-Y-IRS1,p-Y-IRS2 bind PI3K
_doRelease	TRUE
_timestamp	2024-03-20 22:00:59
authored	[InstanceEdit:74816] 2003-07-28 10:05:14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[Complex:74693] PI3K [cytosol] [Homo sapiens] [DefinedSet:112322] p-Y-IRS1,p-Y-IRS2 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:8984312] Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
modified	[InstanceEdit:74960] 2003-07-31 04:59:11 [InstanceEdit:74961] Schmidt, EE, 2003-07-31 04:59:11 [InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:164720] Jassal, Bijay, 2005-06-16 [InstanceEdit:164883] de Bono, B, 2005-07-13 13:57:20 [InstanceEdit:2453745] May, B, 2012-08-15 [InstanceEdit:2453799] May, B, 2012-08-16 [InstanceEdit:5252137] D'Eustachio, Peter, 2014-02-05 [InstanceEdit:5624358] Jupe, Steve, 2014-09-26 [InstanceEdit:5672806] Jupe, Steve, 2015-02-06 [InstanceEdit:5686067] Jupe, Steve, 2015-03-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984379] Duenas, Corina, 2017-04-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
name	p-Y-IRS1,p-Y-IRS2 bind PI3K
negativePrecedingEvent	[NegativePrecedingEvent:9865965] Futile Cycle: GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates
output	[Complex:74694] p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] [Homo sapiens]
precedingEvent	[Reaction:74712] Dissociation of IRS-P from insulin receptor [Homo sapiens] [Reaction:74711] Phosphorylation of IRS [Homo sapiens] [Reaction:2428926] IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 [Homo sapiens] [Reaction:2428930] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 [Homo sapiens] [Reaction:2428922] IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 [Homo sapiens]
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360407] R-HSA-74737.5
summation	[Summation:74739] IRS1, IRS2 and IRS3 are all known to bind the regulatory sub...
(hasEvent)	[Pathway:112399] IRS-mediated signalling [Homo sapiens]
(precedingEvent)	[Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781132] Update Tracker - [Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9784650] Update Tracker - [Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - v53:[add_removeInput]
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No pathways have been reviewed or authored by p-Y-IRS1,p-Y-IRS2 bind PI3K (74737)