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Details on Person GRB2-1:SOS1 binds p-IRS1,p-IRS2

Class:Id	Reaction:74736
_displayName	GRB2-1:SOS1 binds p-IRS1,p-IRS2
_doRelease	TRUE
_timestamp	2024-03-20 22:00:47
authored	[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
figure	[Figure:157818] /figures/Grb2_IRS.jpg
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [DefinedSet:112322] p-Y-IRS1,p-Y-IRS2 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:110025] Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. [LiteratureReference:110026] The function of GRB2 in linking the insulin receptor to Ras signaling pathways. [LiteratureReference:2428918] Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling [LiteratureReference:2445099] Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells [LiteratureReference:2445113] Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts [LiteratureReference:2424290] Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains [LiteratureReference:2454051] Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor
modified	[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:75846] Schmidt, EE, 2003-09-08 11:39:12 [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:77420] Schmidt, EE, 2003-10-27 06:13:17 [InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:112335] Schmidt, EE, 2004-04-27 10:09:34 [InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20 [InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30 [InstanceEdit:157837] Schmidt, EE, 2005-01-07 14:57:32 [InstanceEdit:158561] Schmidt, EE, 2005-02-01 13:03:47 [InstanceEdit:159388] Schmidt, EE, 2005-03-08 11:38:29 [InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07 [InstanceEdit:2453745] May, B, 2012-08-15 [InstanceEdit:2453799] May, B, 2012-08-16 [InstanceEdit:2454055] May, B, 2012-08-19 [InstanceEdit:2671770] D'Eustachio, P, 2012-11-25 [InstanceEdit:5624357] Jupe, Steve, 2014-09-25 [InstanceEdit:5686058] Jupe, Steve, 2015-03-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9030421] Rothfels, Karen, 2017-11-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
name	GRB2-1:SOS1 binds p-IRS1,p-IRS2
negativePrecedingEvent	[NegativePrecedingEvent:9865954] Futile Cycle: GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates
output	[Complex:109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:74712] Dissociation of IRS-P from insulin receptor [Homo sapiens] [Reaction:74711] Phosphorylation of IRS [Homo sapiens] [Reaction:109813] GRB2-1 binds SOS1 [Homo sapiens]
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358624] R-HSA-74736.5
summation	[Summation:77424] Inactive p21ras:GDP is anchored to the plasma membrane by a ...
(hasEvent)	[Pathway:112412] SOS-mediated signalling [Homo sapiens]
(precedingEvent)	[Reaction:109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS [Homo sapiens] [Reaction:109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784853] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v53:[modifyText] [_UpdateTracker:9788335] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v42:[addLiteratureReference]
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