Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The endosome fuses with the plasma membrane allowing the ins...
| Class:Id | Summation:74735 |
|---|---|
| _displayName | The endosome fuses with the plasma membrane allowing the ins... |
| _timestamp | 2003-10-02 12:57:49 |
| created | [InstanceEdit:74816] 2003-07-28 10:05:14 |
| modified | [InstanceEdit:74806] Schmidt, EE, 2003-07-28 08:28:53 [InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13 [InstanceEdit:74961] Schmidt, EE, 2003-07-31 04:59:11 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 |
| text | The endosome fuses with the plasma membrane allowing the insulin receptor to re-integrate there. Any degraded insulin remnants which remained in the endosome are also expelled (The majority having been excreted into the cytoplasm and secreted out of the cell via other mechanisms). The cycle is complete with the dephosphorylated receptor now back in the plasma membrane available to bind the next insulin molecule presented to it. There is some insulin receptor degradation over time when damaged insulin receptors are not recycled but fuse instead with the lysosomes where they are degraded. However the majority of insulin receptors are recycled back to the plasma membrane with greater than 95% efficiency. |
| (summation) | [BlackBoxEvent:74734] Re-integration of insulin receptor into plasma membrane [Homo sapiens] |
| [Change default viewing format] | |
