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Details on Person Insulin receptor de-phosphorylation

Class:Id	Reaction:74733
_displayName	Insulin receptor de-phosphorylation
_doRelease	TRUE
_timestamp	2022-08-30 17:14:29
authored	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
catalystActivity	[CatalystActivity:9815891] protein tyrosine phosphatase activity of PTPN1, PTPRF [endosome membrane]
catalystActivityReference	[CatalystActivityReference:9815888] protein tyrosine phosphatase activity of PTPN1, PTPRF [endosome membrane] Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
figure	[Figure:74810] /figures/ins_dephos.jpg
input	[Complex:77384] p-6Y-insulin receptor [endosome membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:9815887] Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells [LiteratureReference:76082] Intracellular Signal Transduction: The Role of Endosomes [LiteratureReference:76098] Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action. [LiteratureReference:9815894] Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase
modified	[InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13 [InstanceEdit:74960] 2003-07-31 04:59:11 [InstanceEdit:74961] Schmidt, EE, 2003-07-31 04:59:11 [InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:211573] Schmidt, EE, 2008-02-07 14:01:08 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9815890] D'Eustachio, Peter, 2022-08-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Insulin receptor de-phosphorylation
output	[Complex:74706] insulin receptor [endosome membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:74726] Dissociation of insulin from insulin receptor [Homo sapiens] [Reaction:74723] Endosome acidification [Homo sapiens] [BlackBoxEvent:74718] Internalisation of the insulin receptor [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362023] R-HSA-74733.4
summation	[Summation:74754] Endosomal protein tyrosine phosphatases (PTPs) dephosphoryla...
(hasEvent)	[Pathway:77387] Insulin receptor recycling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:74734] Re-integration of insulin receptor into plasma membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779104] Update Tracker - [Reaction:74733] Insulin receptor de-phosphorylation - v66:[modifyText] [_UpdateTracker:9846919] Update Tracker - [Reaction:74733] Insulin receptor de-phosphorylation - v83:[addInput, addLiteratureReference, add_removeCatalystActivity, modifyText]
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