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Details on Person Insulin degradation

Class:Id	BlackBoxEvent:74730
_displayName	Insulin degradation
_doRelease	TRUE
_timestamp	2022-08-31 21:29:08
catalystActivity	[CatalystActivity:74729] endopeptidase activity of IDE, CTSD [endosome lumen]
catalystActivityReference	[CatalystActivityReference:9794497] endopeptidase activity of IDE, CTSD [endosome lumen] Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
compartment	[Compartment:17940] endosome
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
figure	[Figure:76035] /figures/ins_insdeg.jpg
input	[Complex:77385] insulin [endosome lumen] [Homo sapiens]
literatureReference	[LiteratureReference:9816120] Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme [LiteratureReference:9816121] Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D [LiteratureReference:9816124] The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition [LiteratureReference:9794498] Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme [LiteratureReference:9816131] Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism [LiteratureReference:9794501] Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
modified	[InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13 [InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:75843] Schmidt, EE, 2003-09-08 06:32:26 [InstanceEdit:76036] Schmidt, EE, 2003-09-16 06:47:53 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:686123] Jupe, S, 2010-05-06 [InstanceEdit:8864975] Jupe, Steve, 2016-03-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9794499] D'Eustachio, Peter, 2022-07-12 [InstanceEdit:9816122] D'Eustachio, Peter, 2022-08-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Insulin degradation
precedingEvent	[Reaction:74726] Dissociation of insulin from insulin receptor [Homo sapiens] [Reaction:74723] Endosome acidification [Homo sapiens] [BlackBoxEvent:74718] Internalisation of the insulin receptor [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361911] R-HSA-74730.6
summation	[Summation:179342] IDE dimer in the endosome lumen catalyzes the processive deg...
(hasEvent)	[Pathway:77387] Insulin receptor recycling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846834] Update Tracker - [BlackBoxEvent:74730] Insulin degradation - v83:[addLiteratureReference, modifyText] [_UpdateTracker:9847046] Update Tracker - [BlackBoxEvent:74730] Insulin degradation - v82:[add_removeLiteratureReference, modifyText]
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No pathways have been reviewed or authored by Insulin degradation (74730)