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Details on Person Dissociation of insulin from insulin receptor

Class:Id	Reaction:74726
_displayName	Dissociation of insulin from insulin receptor
_doRelease	TRUE
_timestamp	2022-07-12 20:16:31
authored	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
compartment	[Compartment:17940] endosome
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[Complex:74702] Insulin:p-6Y-insulin receptor [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:76093] Insulin degradation: mechanisms, products, and significance. [LiteratureReference:76095] Insulin degradation: progress and potential. [LiteratureReference:76096] Endosomal proteolysis of internalized proteins.
modified	[InstanceEdit:74960] 2003-07-31 04:59:11 [InstanceEdit:74961] Schmidt, EE, 2003-07-31 04:59:11 [InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:83681] Schmidt, EE, 2003-11-25 08:09:26 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:211573] Schmidt, EE, 2008-02-07 14:01:08 [InstanceEdit:5686314] Jupe, Steve, 2015-04-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9794499] D'Eustachio, Peter, 2022-07-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of insulin from insulin receptor
output	[Complex:77384] p-6Y-insulin receptor [endosome membrane] [Homo sapiens] [Complex:77385] insulin [endosome lumen] [Homo sapiens]
precedingEvent	[Reaction:74723] Endosome acidification [Homo sapiens] [Reaction:5252133] ATP6AP1 binds V-ATPase [Homo sapiens] [BlackBoxEvent:74718] Internalisation of the insulin receptor [Homo sapiens] [Reaction:74715] Autophosphorylation of insulin receptor [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359808] R-HSA-74726.4
summation	[Summation:74727] As the endosomal lumen acidifies the insulin dissociates fro...
(hasEvent)	[Pathway:77387] Insulin receptor recycling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:74730] Insulin degradation [Homo sapiens] [Reaction:74733] Insulin receptor de-phosphorylation [Homo sapiens]
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No pathways have been reviewed or authored by Dissociation of insulin from insulin receptor (74726)