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Details on Person Endosome acidification

Class:Id	Reaction:74723
_displayName	Endosome acidification
_doRelease	TRUE
_timestamp	2019-04-25 14:43:43
authored	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
catalystActivity	[CatalystActivity:912612] proton transmembrane transporter activity of V-ATPase:ATP6AP1 [endosome membrane]
compartment	[Compartment:17940] endosome
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
edited	[InstanceEdit:927729] Jassal, B, 2010-08-09
figure	[Figure:74813] /figures/ins_endosacid.jpg
input	[SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:76093] Insulin degradation: mechanisms, products, and significance. [LiteratureReference:76095] Insulin degradation: progress and potential. [LiteratureReference:76096] Endosomal proteolysis of internalized proteins.
modified	[InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13 [InstanceEdit:74960] 2003-07-31 04:59:11 [InstanceEdit:74961] Schmidt, EE, 2003-07-31 04:59:11 [InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 [InstanceEdit:77383] Schmidt, EE, 2003-10-24 07:52:24 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:211573] Schmidt, EE, 2008-02-07 14:01:08 [InstanceEdit:912609] Jassal, B, 2010-07-12 [InstanceEdit:927728] Jassal, B, 2010-08-09 [InstanceEdit:9644853] Jassal, Bijay, 2019-04-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Endosome acidification
output	[SimpleEntity:74722] H+ [endosome lumen]
precedingEvent	[Reaction:5252133] ATP6AP1 binds V-ATPase [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:927730] He, Lei, 2010-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359957] R-HSA-74723.3
summation	[Summation:74753] The effect of the proton pump is to allow entry of [H+] ions...
(hasEvent)	[Pathway:77387] Insulin receptor recycling [Homo sapiens]
(precedingEvent)	[Reaction:74726] Dissociation of insulin from insulin receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790242] Update Tracker - [Reaction:74723] Endosome acidification - v34:[add_removeCatalystActivity]
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No pathways have been reviewed or authored by Endosome acidification (74723)