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Details on Person Internalisation of the insulin receptor

Class:Id	BlackBoxEvent:74718
_displayName	Internalisation of the insulin receptor
_doRelease	TRUE
_timestamp	2024-03-20 22:00:55
authored	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
compartment	[Compartment:74700] endosome membrane [Compartment:876] plasma membrane
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
figure	[Figure:74814] /figures/ins_internal.jpg
goBiologicalProcess	[GO_BiologicalProcess:172011] receptor internalization
input	[Complex:74678] Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:76082] Intracellular Signal Transduction: The Role of Endosomes [LiteratureReference:76086] Compartmentalization of protein traffic in insulin-sensitive cells. [LiteratureReference:76088] Insulin receptor internalization and signalling.
modified	[InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13 [InstanceEdit:74960] 2003-07-31 04:59:11 [InstanceEdit:74961] Schmidt, EE, 2003-07-31 04:59:11 [InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:211573] Schmidt, EE, 2008-02-07 14:01:08 [InstanceEdit:2648974] D'Eustachio, P, 2012-11-21 [InstanceEdit:5624358] Jupe, Steve, 2014-09-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9794448] D'Eustachio, Peter, 2022-07-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
name	Internalisation of the insulin receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865953] Futile Cycle: Dissociation of IRS-P from insulin receptor [NegativePrecedingEvent:9865962] Futile Cycle: Dissociation of p-Y427-SHC1 from insulin receptor
output	[Complex:74702] Insulin:p-6Y-insulin receptor [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:74715] Autophosphorylation of insulin receptor [Homo sapiens] [Reaction:74716] Insulin binds the insulin receptor [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361220] R-HSA-74718.5
summation	[Summation:74725] Almost concomitantly a second effect resulting from the tyro...
(hasEvent)	[Pathway:74752] Signaling by Insulin receptor [Homo sapiens]
(precedingEvent)	[Reaction:74726] Dissociation of insulin from insulin receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778987] Update Tracker - [BlackBoxEvent:74718] Internalisation of the insulin receptor - v66:[modifyText]
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