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Details on Person Under normal physiological conditions blood glucose levels a...
| Class:Id | Summation:74717 |
|---|---|
| _displayName | Under normal physiological conditions blood glucose levels a... |
| _timestamp | 2015-03-27 09:24:07 |
| created | [InstanceEdit:74816] 2003-07-28 10:05:14 |
| literatureReference | [LiteratureReference:5685355] The native alpha 2 beta 2 tetramer is the only subunit structure of the insulin receptor in intact cells and purified receptor preparations |
| modified | [InstanceEdit:74806] Schmidt, EE, 2003-07-28 08:28:53 [InstanceEdit:74811] Schmidt, EE, 2003-07-28 10:05:13 [InstanceEdit:76073] Schmidt, EE, 2003-10-02 08:57:38 [InstanceEdit:77420] Schmidt, EE, 2003-10-27 06:13:17 [InstanceEdit:5685348] Jupe, Steve, 2015-03-27 |
| text | Under normal physiological conditions blood glucose levels are kept under tight control by a series of regulated steps that ensure glucose homeostasis. Upon feeding glucose levels rise and in response to this the body secretes insulin from pancreatic beta-cells into the blood. At physiological concentrations insulin is present in the blood in its monomeric form. The insulin receptor is a tetramer, consisting of two alpha and two beta chains, which are produced by cleavage of a single translated peptide chain (Schenker & Kohanski 1991). Binding of insulin to its receptor occurs on the receptor alpha-subunits. There are two binding domains involved on the receptor (L1 and L2) and it is thought that the amino-terminus of insulin binds with L1 on one of the alpha-subunits and the carboxyterminus with L2 on the other alpha-subunit. The binding of insulin to its receptor causes a conformational change in the alpha-subunits. This in turn produces a conformational change in the beta-subunits leading to the activation of the intrinsic insulin receptor tyrosine kinase. |
| (summation) | [Reaction:74716] Insulin binds the insulin receptor [Homo sapiens] |
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