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Details on Person Dissociation of IRS-P from insulin receptor

Class:Id	Reaction:74712
_displayName	Dissociation of IRS-P from insulin receptor
_doRelease	TRUE
_timestamp	2024-02-20 19:21:52
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[Complex:74695] p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:8984312] Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin [LiteratureReference:9861451] Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
modified	[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:113846] Schmidt, EE, 2004-06-23 11:28:38 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5686067] Jupe, Steve, 2015-03-31 [InstanceEdit:5686314] Jupe, Steve, 2015-04-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984379] Duenas, Corina, 2017-04-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861448] D'Eustachio, Peter, 2024-02-20
name	Dissociation of IRS-P from insulin receptor
output	[Complex:74678] Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens] [DefinedSet:112322] p-Y-IRS1,p-Y-IRS2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:74711] Phosphorylation of IRS [Homo sapiens] [Reaction:74707] Binding of IRS to insulin receptor [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360002] R-HSA-74712.5
summation	[Summation:178688] At the beginning of this reaction, 1 molecule of 'phospho-IR...
(hasEvent)	[Pathway:74713] IRS activation [Homo sapiens]
(precedingEvent)	[Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 [Homo sapiens] [Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K [Homo sapiens] [Reaction:74747] Dephosphorylation of p-Y-IRS1,p-Y-IRS2 [Homo sapiens] [NegativePrecedingEvent:9865953] Futile Cycle: Dissociation of IRS-P from insulin receptor [NegativePrecedingEvent:9865956] Futile Cycle: Dissociation of IRS-P from insulin receptor [NegativePrecedingEvent:9865957] Futile Cycle: Dissociation of IRS-P from insulin receptor [NegativePrecedingEvent:9865966] Futile Cycle: Dissociation of IRS-P from insulin receptor
(updatedInstance)	[_UpdateTracker:9781153] Update Tracker - [Reaction:74712] Dissociation of IRS-P from insulin receptor - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9784764] Update Tracker - [Reaction:74712] Dissociation of IRS-P from insulin receptor - v53:[add_removeOutput] [_UpdateTracker:9864246] Update Tracker - [Reaction:74712] Dissociation of IRS-P from insulin receptor - v88:[add_removeLiteratureReference]
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