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Details on Person Phosphorylation of IRS

Class:Id	Reaction:74711
_displayName	Phosphorylation of IRS
_doRelease	TRUE
_timestamp	2016-11-10 00:54:56
catalystActivity	[CatalystActivity:74710] transmembrane receptor protein tyrosine kinase activity of IRS:Insulin:p-6Y-Insulin receptor [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[Complex:74699] IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:2252571] siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
modified	[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:113846] Schmidt, EE, 2004-06-23 11:28:38 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:164720] Jassal, Bijay, 2005-06-16 [InstanceEdit:2252574] May, B, 2012-05-16 [InstanceEdit:5252137] D'Eustachio, Peter, 2014-02-05 [InstanceEdit:5686067] Jupe, Steve, 2015-03-31 [InstanceEdit:5686314] Jupe, Steve, 2015-04-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of IRS
output	[Complex:74695] p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:74707] Binding of IRS to insulin receptor [Homo sapiens] [Reaction:74715] Autophosphorylation of insulin receptor [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361896] R-HSA-74711.3
summation	[Summation:179065] At the beginning of this reaction, 1 molecule of 'ATP', and ...
(hasEvent)	[Pathway:74713] IRS activation [Homo sapiens]
(precedingEvent)	[Reaction:74712] Dissociation of IRS-P from insulin receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788655] Update Tracker - [Reaction:74711] Phosphorylation of IRS - v41:[addLiteratureReference]
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No pathways have been reviewed or authored by Phosphorylation of IRS (74711)