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Details on Person Binding of IRS to insulin receptor

Class:Id	Reaction:74707
_displayName	Binding of IRS to insulin receptor
_doRelease	TRUE
_timestamp	2024-03-20 22:00:31
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
input	[Complex:74678] Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens] [DefinedSet:198273] IRS1,2 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:8984302] The IRS-signalling system: a network of docking proteins that mediate insulin action [LiteratureReference:1168874] SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
modified	[InstanceEdit:74962] Schmidt, EE, 2003-07-31 08:01:54 [InstanceEdit:77390] Schmidt, EE, 2003-10-24 10:45:23 [InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:113846] Schmidt, EE, 2004-06-23 11:28:38 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:164720] Jassal, Bijay, 2005-06-16 [InstanceEdit:5252137] D'Eustachio, Peter, 2014-02-05 [InstanceEdit:5624357] Jupe, Steve, 2014-09-25 [InstanceEdit:5686055] Jupe, Steve, 2015-03-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984379] Duenas, Corina, 2017-04-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9676735] D'Eustachio, Peter, 2020-02-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865967] Orlic-Milacic, Marija, 2024-03-20
name	Binding of IRS to insulin receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865958] Futile Cycle: Dephosphorylation of p-Y-IRS1,p-Y-IRS2 [NegativePrecedingEvent:9865957] Futile Cycle: Dissociation of IRS-P from insulin receptor [NegativePrecedingEvent:9865959] Futile Cycle: Dissociation of p-Y427-SHC1 from insulin receptor
output	[Complex:74699] IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:74715] Autophosphorylation of insulin receptor [Homo sapiens] [Reaction:74716] Insulin binds the insulin receptor [Homo sapiens]
regulatedBy	[NegativeRegulation:110016] Negative regulation by 'GRB10:INSR [plasma membrane]'
regulationReference	[RegulationReference:9642069] Negative regulation by 'GRB10:INSR [plasma membrane]' Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359739] R-HSA-74707.8
summation	[Summation:178515] Using receptor mutagenesis studies it is known that IRS1 via...
(hasEvent)	[Pathway:74713] IRS activation [Homo sapiens]
(precedingEvent)	[Reaction:74711] Phosphorylation of IRS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777094] Update Tracker - [Reaction:74707] Binding of IRS to insulin receptor - v72:[add_removeInput] [_UpdateTracker:9781266] Update Tracker - [Reaction:74707] Binding of IRS to insulin receptor - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9784771] Update Tracker - [Reaction:74707] Binding of IRS to insulin receptor - v53:[modifyText] [_UpdateTracker:9786094] Update Tracker - [Reaction:74707] Binding of IRS to insulin receptor - v50:[add_removeRegulator]
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