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Details on Person UniProt:P08168 SAG
| Class:Id | ReferenceGeneProduct:74547 |
|---|---|
| _chainChangeLog | chain:1-404 added on Fri February 6 2015;chain:5-404 added on Fri February 6 2015 |
| _displayName | UniProt:P08168 SAG |
| _timestamp | 2024-08-09 19:18:55 |
| chain | chain:1-404 chain:5-404 |
| checksum | 26B1D80B652AF1EF |
| comment | FUNCTION Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (PubMed:25205354, PubMed:8003967). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (By similarity).SUBUNIT Monomer (PubMed:21288033). Homodimer (PubMed:10219246, PubMed:21288033, PubMed:26510463). Homotetramer (PubMed:10219246, PubMed:21288033). Self-association is cooperative (PubMed:21288033). Isoform A and isoform B interact with RHO (via phosphorylated C-terminus) (PubMed:10219246, PubMed:23604253, PubMed:25205354, PubMed:8003967).INTERACTION Highly expressed in photoreceptor outer segments in light-exposed retina (PubMed:7515057). Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (PubMed:7515057). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (By similarity).SUBCELLULAR LOCATION Detected in retina, in rod photoreceptor cells (at protein level) (PubMed:7515057, PubMed:8003967).DOMAIN The C-terminus of isoform A interferes with binding to non-phosphorylated RHO. Interaction with phosphorylated RHO triggers displacement of the C-terminus and leads to a conformation change that mediates high-affinity RHO binding. Isoform B is C-terminally truncated and is therefore already in the optimal conformation for RHO binding.SIMILARITY Belongs to the arrestin family. |
| description | recommendedName: S-arrestin alternativeName: 48 kDa protein alternativeName: fullName evidence="13"Retinal S-antigen shortName: S-AG alternativeName: Rod photoreceptor arrestin component recommendedName: S-arrestin short form /component |
| geneName | SAG |
| identifier | P08168 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell projection Direct protein sequencing Membrane Phosphoprotein Reference proteome |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | SAG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ARRS_BOVIN |
| sequenceLength | 404 |
| species | [Species:48898] Bos taurus |
| (isoformParent) | [ReferenceIsoform:144202] UniProt:P08168-2 SAG [Bos taurus] [ReferenceIsoform:402578] UniProt:P08168-1 SAG [Bos taurus] |
| (referenceEntity) | [EntityWithAccessionedSequence:74548] Sag [cytosol] [Bos taurus] [EntityWithAccessionedSequence:75329] phospho-arrestin [cytosol] [Bos taurus] |
| (referenceSequence) | [ModifiedResidue:75328] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:P08168 SAG (74547)
