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Details on Person UniProt:Q63651 Grk1
| Class:Id | ReferenceGeneProduct:74522 |
|---|---|
| _chainChangeLog | chain:1-561 added on Fri February 6 2015;propeptide:562-564 added on Fri February 6 2015 |
| _displayName | UniProt:Q63651 Grk1 |
| _timestamp | 2025-02-21 19:48:27 |
| chain | chain:1-561 propeptide:562-564 |
| checksum | 17E05784E6D1ED00 |
| comment | FUNCTION Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (By similarity). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).CATALYTIC ACTIVITY L-threonyl-[rhodopsin] + ATP = O-phospho-L-threonyl-[rhodopsin] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[rhodopsin] + ATP = O-phospho-L-seryl-[rhodopsin] + ADP + H(+)ACTIVITY REGULATION Inhibited by RCVRN, which prevents the interaction between GRK1 and RHO (By similarity). Inhibition is calcium-dependent (By similarity).SUBUNIT Interacts (via N-terminus) with RCVRN (via C-terminus); the interaction is Ca(2+)-dependent (By similarity). Interacts (when prenylated) with PDE6D; this promotes release from membranes (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity).SUBCELLULAR LOCATION Subcellular location is not affected by light or dark conditions.TISSUE SPECIFICITY Detected in retina (at protein level) (PubMed:21504899). Retina-specific. Expressed in rod and cone photoreceptor cells.PTM Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.PTM Farnesylation is required for full activity.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
| description | recommendedName: Rhodopsin kinase GRK1 shortName: RK ecNumber evidence="3"2.7.11.14 alternativeName: fullName evidence="12"G protein-coupled receptor kinase 1 |
| geneName | Grk1 Rhok |
| identifier | Q63651 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell projection Direct protein sequencing Kinase Lipoprotein Membrane Methylation Nucleotide-binding Phosphoprotein Prenylation Reference proteome Sensory transduction Serine/threonine-protein kinase Transferase Vision |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Grk1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GRK1_RAT |
| sequenceLength | 564 |
| species | [Species:48895] Rattus norvegicus |
| (referenceEntity) | [EntityWithAccessionedSequence:74523] Rhodopsin kinase [cytosol] [Rattus norvegicus] [EntityWithAccessionedSequence:74525] farnesylated rhodopsin kinase [Rattus norvegicus] |
| (referenceSequence) | [ModifiedResidue:74524] farnesylated residue at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q63651 Grk1 (74522)
