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Details on Person UniProt:P28327 GRK1
| Class:Id | ReferenceGeneProduct:74497 |
|---|---|
| _chainChangeLog | chain:1-558 added on Sat February 7 2015;propeptide:559-561 added on Sat February 7 2015 |
| _displayName | UniProt:P28327 GRK1 |
| _timestamp | 2025-02-21 19:48:27 |
| chain | chain:1-558 propeptide:559-561 |
| checksum | 1AC6FEC1B277DDD8 |
| comment | FUNCTION Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:12686556, PubMed:16675451, PubMed:21299498). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).CATALYTIC ACTIVITY L-threonyl-[rhodopsin] + ATP = O-phospho-L-threonyl-[rhodopsin] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[rhodopsin] + ATP = O-phospho-L-seryl-[rhodopsin] + ADP + H(+)ACTIVITY REGULATION Inhibited by RCVRN, which prevents the interaction between GRK1 and RHO (PubMed:12686556, PubMed:21299498). Inhibition is calcium-dependent (PubMed:12686556).SUBUNIT Interacts (via N-terminus) with RCVRN (via C-terminus); the interaction is Ca(2+)-dependent (PubMed:16675451, PubMed:17020884, PubMed:21299498, PubMed:24189072, PubMed:26584024). Interacts (when prenylated) with PDE6D; this promotes release from membranes (PubMed:14561760). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (PubMed:17020884).INTERACTION Subcellular location is not affected by light or dark conditions.TISSUE SPECIFICITY Rod outer segments of retina photoreceptor cells (at protein level) (PubMed:1527025, PubMed:1656454, PubMed:1730692). Retina (PubMed:1656454).PTM Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-488 and Thr-489. Phosphorylation at Ser-21 is regulated by light and activated by cAMP (Probable).PTM Farnesylation is required for full activity.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
| description | recommendedName: Rhodopsin kinase GRK1 shortName: RK ecNumber evidence="7 9 11 13 15"2.7.11.14 alternativeName: G protein-coupled receptor kinase 1 |
| geneName | GRK1 RHOK |
| identifier | P28327 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell projection Direct protein sequencing Kinase Lipoprotein Membrane Methylation Nucleotide-binding Phosphoprotein Prenylation Reference proteome Sensory transduction Serine/threonine-protein kinase Transferase Vision |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GRK1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GRK1_BOVIN |
| sequenceLength | 561 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:74500] farnesylated rhodopsin kinase [plasma membrane] [Bos taurus] [EntityWithAccessionedSequence:74516] Rhodopsin kinase [cytosol] [Bos taurus] [EntityWithAccessionedSequence:3274475] S-farn-Grk1 [photoreceptor disc membrane] [Bos taurus] |
| (referenceSequence) | [ModifiedResidue:74499] farnesylated residue at unknown position [GroupModifiedResidue:3274482] S-farnesyl-L-cysteine (farnesyl group) at 558 |
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No pathways have been reviewed or authored by UniProt:P28327 GRK1 (74497)
