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Details on Person Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Class:Id	Reaction:744887
_displayName	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
_doRelease	TRUE
_timestamp	2020-02-21 13:27:23
authored	[InstanceEdit:749459] Jupe, S, 2010-05-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:744888] Jupe, S, 2010-05-18
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
input	[DefinedSet:391181] Ligand:GPCR complexes that activate Gs [plasma membrane] [Homo sapiens] [Complex:391179] Heterotrimeric G-protein Gs (inactive) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:425625] Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus
modified	[InstanceEdit:744889] Jupe, S, 2010-05-18 [InstanceEdit:749449] Jupe, S, 2010-05-18 [InstanceEdit:751025] Jupe, S, 2010-05-19 [InstanceEdit:813670] Jupe, S, 2010-05-26 [InstanceEdit:8982644] Varusai, Thawfeek, 2017-03-21 [InstanceEdit:8982708] Varusai, Thawfeek, 2017-03-22 [InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11 [InstanceEdit:9024676] Jupe, Steve, 2017-10-06 [InstanceEdit:9660823] Murillo, Julieth, 2019-09-12 [InstanceEdit:9676822] Jassal, Bijay, 2020-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
output	[Complex:744885] Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:390674] ADRB1 bind ADR,NAd [Homo sapiens] [Reaction:9611751] β1,2-agonists bind ADRB1,2 [Homo sapiens] [Reaction:9611721] β1-agonists bind ADRB1 [Homo sapiens] [Reaction:390835] DRD1,5 bind DA [Homo sapiens] [Reaction:390909] HRH2 binds hist [Homo sapiens] [Reaction:390931] 5-HT4, 6 and 7 receptors can bind serotonin [Homo sapiens] [Reaction:391211] Trace amine-associated receptors can bind trace amines [Homo sapiens] [Reaction:391378] Follicle-stimulating hormone receptor can bind FSH [Homo sapiens] [Reaction:391377] Luteinizing hormone receptor can bind LH [Homo sapiens] [Reaction:391942] IP receptor can bind prostacyclin [Homo sapiens] [Reaction:391375] TSHR binds TSH/Thyrostimulin [Homo sapiens] [BlackBoxEvent:9965856] Expression of TSHR [Homo sapiens] [Reaction:418925] ADORA2A,B bind Ade-Rib [Homo sapiens] [Reaction:392263] AVP(20-28) binds AVPR2 [Homo sapiens] [Reaction:420265] AMY1-3 bind IAPP(34-70) [Homo sapiens] [Reaction:419843] CALCA(83-119) binds CALCR [Homo sapiens] [Reaction:420127] CGRP receptor can bind calcitonin gene-related peptides [Homo sapiens] [Reaction:420173] CRHR1,CRHR2-1 binds CRH,UCN [Homo sapiens] [Reaction:420214] The adrenomedullin receptor can bind adrenomedullin and intermedin [Homo sapiens] [Reaction:420274] GIP receptor binds gastric inhibitory peptide [Homo sapiens] [Reaction:163625] Glucagon binds to Glucagon receptor [Homo sapiens] [Reaction:420123] Glucagon-like receptor 2 binds GLP2 [Homo sapiens] [Reaction:381612] GLP1R binds GLP1 [Homo sapiens] [BlackBoxEvent:383313] Glucagon-like Peptide 1 is secreted from intestinal L cells [Homo sapiens] [Reaction:420243] GHRH receptor binds GHRH [Homo sapiens] [Reaction:420131] The PACAP receptor binds PACAP [Homo sapiens] [Reaction:420233] VIP receptors bind VIP [Homo sapiens] [Reaction:420489] Parathyroid hormone receptor can bind parathyroid hormone [Homo sapiens] [Reaction:420202] Secretin receptor binds secretin [Homo sapiens] [Reaction:444620] Neuropeptide S receptor binds neuropeptide S [Homo sapiens] [Reaction:444838] Relaxin receptor 1 binds relaxin 2 and 3 [Homo sapiens] [Reaction:444879] Relaxin receptor 2 binds relaxin 2 and INSL3 [Homo sapiens] [Reaction:444654] G-protein coupled bile acid receptor binds lithocholic acid [Homo sapiens] [Reaction:444572] Zinc is an agonist of GPR39 [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104322] R-HSA-744887.4
summation	[Summation:391178] The role of the guanine nucleotide-binding protein G alpha-s...
(hasEvent)	[Pathway:418555] G alpha (s) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:379044] Liganded Gs-activating GPCR acts as a GEF for Gs [Homo sapiens] [Reaction:9660824] ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs [Homo sapiens]
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